In the aquatic environment, the interaction between environmental pollution is very complex, including pesticides and antibiotics are dominant. However, most studies only focus on the toxic effects of individual, not composite. In this study, the effect of sub-chronic exposure sipermetrin (CMN, 0.65 mg / L), sulfamethoxazole (SMZ, 0.30 mg / L) and mix them in the grass crap (Ctenopharyngodon idellus) was investigated. Brain tight junctions, and indices of oxidative stress associated with apoptosis was determined after 42 days of exposure. In terms of brain function, acetyl cholinesterase (AChE) activity was significantly inhibited by CMN, SMZ and mix them during the period of exposure. clear histological damage of cellular and subcellular levels was also observed, which is further confirmed by decreased levels of tight junction proteins. Malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG) significantly increased contents of individual compounds and mixtures, where the content of glutathione (GSH) is shown the opposite trend. In the mechanism, nuclear factor (erythrocytes derived 2) as 2 (Nrf2) pathway is activated, which can trigger cell protection to cope with CMN and SMZ exposure. However, apoptosis was also detected on the mRNA level and histochemistry. In general, both exogenously induced the same biological response. Neurotoxicity of CMN reinforced by SMZ associated with this index in many cases and vice versa. This study will reveal the risk of co-ecological potential of pesticides and antibiotics in aquatic organisms, and provide the basic data for the assessment of safety and risk.

Long non-coding RNAs GHET1 / miR-105 / RAP2B axis regulates the development of acute myeloid leukemia

Background: To explore the molecular mechanism of biological effects and potential long non-coding RNA (lncRNA) gastric carcinoma proliferation increases transcript 1 (GHET1) in acute myeloid leukemia (AML). Methods: Fluorescence in situ hybridization performed to determine the location GHET1. Quantitative polymerase chain reaction (qPCR) was performed to verify the RNA expression. GHET1 excess and knockdown achieved by transfection of the expression vector or short hairpin RNA. Western blotting, qPCR, Cell Counting Kit-8 assay, JC-1 staining and flow cytometry was conducted to measure the function GHET1. Dual luciferase reporter assay was conducted to confirm the relationship between microRNA 105 (miR-105) and Ras-related protein Rap-2B (RAP2B). Results: GHET1 localized in the nucleus of the cell line NB4. Expression GHET1 appointed in AML cell lines compared with normal bone marrow mononuclear cells. GHET1 knockdown led to inhibition of proliferation and promoted differentiation and apoptosis of AML cell lines. Subsequently, directly tied GHET1 miR-105 and miR-105 downregulated expression. MiR-105 suppressed excessive proliferation and induction of differentiation and apoptosis of AML cell lines. Additionally, RAP2B confirmed to be the target of miR-105 gene and demonstrated an inverse correlation between the level of their expression in AML cell lines; when miR-105 increased, the rate of Rap-2B decreases and vice versa. Conclusion: This study shows that GHET1 / miR-105 / Rap2B axis may be important signaling pathways involved in the development of AML.
external stimuli is a powerful tool that Nature uses to control the function and activity of proteins. For example, during viral entry and exit, the pH variation is known to trigger large conformational changes of proteins. In Nature, as well as electron transfer (ET) ET protein properties affected by pH-induced conformational changes. In this work, 3 10 -helix conversion pH controlled, reversible for α-helix (of acidic pH values ​​were very basic and otherwise) of the peptide supramolecular systems are built on a gold surface is described.

Environmentally relevant concentration of cypermethrin or/and sulfamethoxazole induce neurotoxicity of grass carp: Involvement of blood-brain barrier, oxidative stress and apoptosis
Environmentally relevant concentration of cypermethrin or/and sulfamethoxazole induce neurotoxicity of grass carp: Involvement of blood-brain barrier, oxidative stress and apoptosis

Causal Relationship between Plasma Adiponectin and Body Mass Index: One-and two-sample two-way Mendelian Randomization Analysis on 460 397 Individuals

Background: Adiponectin is a protein hormone produced by adipocytes may play an important role in obesity. However, a causal association between plasma adiponectin and body mass index (BMI) is still uncertain. We tested the hypothesis that (a) plasma adiponectin and BMI were inversely associated observational, (b) genetically high BMI is associated with lower plasma adiponectin, and (c) genetic plasma adiponectin are associated with a lower BMI.
Methods: Information about 108 896 people from the Copenhagen General Population Study used in the Mendelian randomization analysis sample observational and a two-way, using the five genetic variants for BMI and 3 for adiponectin. For independent confirmation, information about 322 154 people from the GIANT consortium, and 29 347 people from the consortium ADIPOGen Mendelian randomization used in the analysis of two samples in two directions, using 68 genetic variants for BMI and 14 for adiponectin.
Results: In the observational analysis, an increase of 1 kg / m2 in BMI was associated with a 0.44 ug / mL (95% confidence interval: -0.46, -0.42) in plasma adiponectin, while an increase of 1 mg / mL in adiponectin plasma is associated with -0.11 kg / m2 (-0.12, -0.11) in BMI. In the causal genetic analysis, no relationship was observed between BMI and plasma adiponectin and vice versa. In the sample of Mendelian randomization analysis, 1 kg / m2 increase in BMI is determined genetically associated with -0.13 ug / mL (-0.53, 0.28) in plasma adiponectin, while the 1 mg / mL increase in genetically determined on plasma adiponectin was associated with a 0.01 kg / m2 (-0.05, 0.07) in BMI. As expected in the two-sample Mendelian randomization analysis was 0.03 mg / mL (-0.02, 0.07) and 0.03 kg / m2 (-0.02, 0.07), respectively.

p38

MBS8533658-01mLAF635 0.1mL(AF635)
EUR 565

P38 mAb

MBS435304-005mL 0.05mL
EUR 415

P38 mAb

MBS435304-01mL 0.1mL
EUR 660

P38 mAb

MBS435304-5x01mL 5x0.1mL
EUR 2655

p38 MAPK

E8ET1702-65 100ul
EUR 275
Description: Available in various conjugation types.

Mxi2, p38

MBS603655-01mg 0.1mg
EUR 820

Mxi2, p38

MBS603655-5x01mg 5x0.1mg
EUR 3530

p38 MAPK

MBS8534372-01mL 0.1mL
EUR 345

p38 MAPK

MBS8534372-01mLAF405L 0.1mL(AF405L)
EUR 565

p38 MAPK

MBS8534372-01mLAF405S 0.1mL(AF405S)
EUR 565

p38 MAPK

MBS8534372-01mLAF610 0.1mL(AF610)
EUR 565

p38 MAPK

MBS8534372-01mLAF635 0.1mL(AF635)
EUR 565

p38 protein

E20-80078 20ug
EUR 275
Description: N/A

p38 protein

E20-80079 20ug
EUR 275
Description: N/A

p38 protein

MBS8526800-002mg 0.02mg
EUR 345

p38 protein

MBS8526800-5x002mg 5x0.02mg
EUR 1410

p38 protein

MBS8526801-002mg 0.02mg
EUR 345

p38 protein

MBS8526801-5x002mg 5x0.02mg
EUR 1410

p38 Antibody

20-abx141038
  • Ask for price
  • Ask for price
  • Ask for price
  • 30 ul
  • 100 ul
  • 200 ul

p38 Antibody

20-abx133223
  • Ask for price
  • Ask for price
  • Ask for price
  • 30 ul
  • 100 ul
  • 200 ul

p38 Antibody

abx236076-100g 100 µg
EUR 350

p38 Antibody

abx236076-100ug 100 ug
EUR 577.2

p38 Antibody

48644 100ul
EUR 499

p38 Antibody

48644-100ul 100ul
EUR 399.6

p38 Antibody

48644-50ul 50ul
EUR 286.8

p38 antibody

70R-51505 100 ul
EUR 242
Description: Purified Polyclonal p38 antibody

p38 antibody

70R-51506 100 ul
EUR 286
Description: Purified Polyclonal p38 antibody

p38 Antibody

35478 100ul
EUR 479

p38 Antibody

35478-100ul 100ul
EUR 468

p38 Antibody

B7178-100ul 100μl
EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody

B7178-50ul 50μl
EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody

20-abx007541
  • Ask for price
  • Ask for price
  • Ask for price
  • 30 ul
  • 100 ul
  • 200 ul

p38 Antibody

B0798-100ul 100μl
EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody

B0798-50ul 50μl
EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody

B0799-100ul 100μl
EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody

B0799-50ul 50μl
EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody

E38PA3186 100ul
EUR 225
Description: Available in various conjugation types.

p38 Antibody

E38PA4721 100ul
EUR 225
Description: Available in various conjugation types.

p38 Antibody

E38PA5060 100ul
EUR 225
Description: Available in various conjugation types.

p38 Antibody

E38PA5094 100ul
EUR 225
Description: Available in various conjugation types.

p38 Antibody

E38PA7126 100ul
EUR 225
Description: Available in various conjugation types.

p38 Antibody

MBS5316121-01mL 0.1mL
EUR 460

p38 Antibody

MBS5316121-5x01mL 5x0.1mL
EUR 1920

p38 Antibody

MBS5316122-01mL 0.1mL
EUR 535

p38 Antibody

MBS5316122-5x01mL 5x0.1mL
EUR 2270

p38 Antibody

MBS8002013-0025mL 0.025mL
EUR 315

p38 Antibody

MBS8002013-5x0025mL 5x0.025mL
EUR 890

p38 Antibody

MBS805089-01mL 0.1mL
EUR 425

p38 Antibody

MBS805089-5x01mL 5x0.1mL
EUR 1350

p38 Antibody

MBS806203-0025mL 0.025mL
EUR 320

p38 Antibody

MBS8584173-01mL 0.1mL
EUR 305

p38 Antibody

MBS8584173-01mLAF405L 0.1mL(AF405L)
EUR 465

p38 Antibody

MBS8584173-01mLAF405S 0.1mL(AF405S)
EUR 465

p38 Antibody

MBS8584173-01mLAF610 0.1mL(AF610)
EUR 465

p38 Antibody

MBS8584173-01mLAF635 0.1mL(AF635)
EUR 465

p38 Antibody

MBS8582905-01mL 0.1mL
EUR 305

p38 Antibody

MBS8582905-01mLAF405L 0.1mL(AF405L)
EUR 465

p38 Antibody

MBS8582905-01mLAF405S 0.1mL(AF405S)
EUR 465

p38 Antibody

MBS8582905-01mLAF610 0.1mL(AF610)
EUR 465

p38 Antibody

MBS8582905-01mLAF635 0.1mL(AF635)
EUR 465

p38 Antibody

MBS8582923-01mL 0.1mL
EUR 305

p38 Antibody

MBS8582923-01mLAF405L 0.1mL(AF405L)
EUR 465

p38 Antibody

MBS8582923-01mLAF405S 0.1mL(AF405S)
EUR 465

p38 Antibody

MBS8582923-01mLAF610 0.1mL(AF610)
EUR 465

p38 Antibody

MBS8582923-01mLAF635 0.1mL(AF635)
EUR 465

p38 Antibody

MBS8582665-01mL 0.1mL
EUR 305

p38 Antibody

MBS8582665-01mLAF405L 0.1mL(AF405L)
EUR 465

p38 Antibody

MBS8582665-01mLAF405S 0.1mL(AF405S)
EUR 465

p38 Antibody

MBS8582665-01mLAF610 0.1mL(AF610)
EUR 465

p38 Antibody

MBS8582665-01mLAF635 0.1mL(AF635)
EUR 465

p38 Antibody

MBS8581787-01mL 0.1mL
EUR 305

p38 Antibody

MBS8581787-01mLAF405L 0.1mL(AF405L)
EUR 465

p38 Antibody

MBS8581787-01mLAF405S 0.1mL(AF405S)
EUR 465

p38 Antibody

MBS8581787-01mLAF610 0.1mL(AF610)
EUR 465

p38 Antibody

MBS8581787-01mLAF635 0.1mL(AF635)
EUR 465

p38 Antibody

MBS9508977-005mL 0.05mL
EUR 285

p38 Antibody

MBS9508977-01mL 0.1mL
EUR 385

p38 Antibody

MBS9508977-5x01mL 5x0.1mL
EUR 1590

p38 Antibody

MBS9435492-005mL 0.05mL
EUR 325

p38 Antibody

MBS9435492-01mL 0.1mL
EUR 435

p38 Antibody

MBS9435492-5x01mL 5x0.1mL
EUR 1810

p38 Antibody

MBS9409774-01mL 0.1mL
EUR 420

p38 Antibody

MBS9409774-5x01mL 5x0.1mL
EUR 1740

p38 Antibody

SPC-172D 0.1ml
EUR 161
Description: Rabbit Anti-Human p38 Polyclonal

p38 Antibody

SPC-172S 0.012ml Ask for price
Description: Rabbit Anti-Human p38 Polyclonal

p38 Substrate

MBS517838-1mg 1mg
EUR 205

p38 Substrate

MBS517838-5x1mg 5x1mg
EUR 675

MAP Kinase p38, Control Cell Extracts (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS657552-10Blots 10Blots
EUR 430

MAP Kinase p38, Control Cell Extracts (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS657552-5x10Blots 5x10Blots
EUR 1785

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS632290-02mL 0.2mL
EUR 660

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS632290-5x02mL 5x0.2mL
EUR 2810

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS627818-10Blots 10Blots
EUR 875

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS627818-5x10Blots 5x10Blots
EUR 3785

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS633592-01mL 0.1mL
EUR 695

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS633592-5x01mL 5x0.1mL
EUR 2985

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS630803-02mL 0.2mL
EUR 650

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS630803-06mL 0.6mL
EUR 1175

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)

MBS630803-5x06mL 5x0.6mL
EUR 5140

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor

E1B1863 1mg
EUR 85

SB-203580 p38 MAPK (p38 MAP kinase) Inhibitor

MBS8579825-1mg 1mg
EUR 180

SB-203580 p38 MAPK (p38 MAP kinase) Inhibitor

MBS8579825-5x1mg 5x1mg
EUR 660

p38 (411-425) M.leprae

MBS8246858-10mg 10mg
EUR 675

p38 (411-425) M.leprae

MBS8246858-1mg 1mg
EUR 255

p38 (411-425) M.leprae

MBS8246858-5mg 5mg
EUR 480

p38 (411-425) M.leprae

MBS8246858-5x10mg 5x10mg
EUR 2955

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38) (Agarose)

MBS631660-04mL 0.4mL
EUR 670

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38) (Agarose)

MBS631660-5x04mL 5x0.4mL
EUR 2870

Anti - p38-a

MBS684252-002mL 0.02mL
EUR 270

Anti - p38-a

MBS684252-005mL 0.05mL
EUR 485

Anti - p38-a

MBS684252-01mL 0.1mL
EUR 720

Anti - p38-a

MBS684252-5x01mL 5x0.1mL
EUR 2925

Anti - p38-b

MBS684253-002mL 0.02mL
EUR 270

Anti - p38-b

MBS684253-005mL 0.05mL
EUR 485

Anti - p38-b

MBS684253-01mL 0.1mL
EUR 720

Anti - p38-b

MBS684253-5x01mL 5x0.1mL
EUR 2925

Anti - p38-g

MBS684254-002mL 0.02mL
EUR 270

Anti - p38-g

MBS684254-005mL 0.05mL
EUR 485

Anti - p38-g

MBS684254-01mL 0.1mL
EUR 720

Anti - p38-g

MBS684254-5x01mL 5x0.1mL
EUR 2925

Anti - p38-d

MBS684255-002mL 0.02mL
EUR 270

Anti - p38-d

MBS684255-005mL 0.05mL
EUR 485

Anti - p38-d

MBS684255-01mL 0.1mL
EUR 720

Anti - p38-d

MBS684255-5x01mL 5x0.1mL
EUR 2925

p38 Mouse mAb

E2222580 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

p38 Mouse mAb

E2220879 100ul
EUR 225
Description: Available in various conjugation types.

p38 Mouse mAb

MBS8539086-01mL 0.1mL
EUR 305

p38 Mouse mAb

MBS8539086-01mLAF405L 0.1mL(AF405L)
EUR 565

p38 Mouse mAb

MBS8539086-01mLAF405S 0.1mL(AF405S)
EUR 565

p38 Mouse mAb

MBS8539086-01mLAF610 0.1mL(AF610)
EUR 565

p38 Mouse mAb

MBS8539086-01mLAF635 0.1mL(AF635)
EUR 565

p38 Rabbit mAb

E2R25239 100μl
EUR 225
Description: Available in various conjugation types.

p38 Rabbit mAb

E2R27123 100μl
EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb

E2251338 100ul
EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb

E2251719 100ul
EUR 225
Description: Available in various conjugation types.

p38 Rabbit mAb

E38A4061 100ug/100ul
EUR 255

p38 Rabbit pAb

E2340697 100ul
EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb

E2380881 100ul
EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb

E2381051 100ul
EUR 225
Description: Available in various conjugation types.

p38 Rabbit mAb

MBS4752931-01mL 0.1mL
EUR 450

p38 Rabbit mAb

MBS4752931-5x01mL 5x0.1mL
EUR 1540

p38 Rabbit mAb

MBS4754198-01mL 0.1mL
EUR 450

p38 Rabbit mAb

MBS4754198-5x01mL 5x0.1mL
EUR 1540

p38 HOG Kinase

MBS395428-025mg 0.25mg
EUR 425

p38 HOG Kinase

MBS395428-5x025mg 5x0.25mg
EUR 1760

p38 Rabbit pAb

MBS8539985-01mL 0.1mL
EUR 305

p38 Rabbit pAb

MBS8539985-01mLAF405L 0.1mL(AF405L)
EUR 565

p38 Rabbit pAb

MBS8539985-01mLAF405S 0.1mL(AF405S)
EUR 565

p38 Rabbit pAb

MBS8539985-01mLAF610 0.1mL(AF610)
EUR 565

p38 Rabbit pAb

MBS8539985-01mLAF635 0.1mL(AF635)
EUR 565

p38 Rabbit pAb

MBS8540327-01mL 0.1mL
EUR 305

p38 Rabbit pAb

MBS8540327-01mLAF405L 0.1mL(AF405L)
EUR 565

p38 Rabbit pAb

MBS8540327-01mLAF405S 0.1mL(AF405S)
EUR 565

p38 Rabbit pAb

MBS8540327-01mLAF610 0.1mL(AF610)
EUR 565

p38 Rabbit pAb

MBS8540327-01mLAF635 0.1mL(AF635)
EUR 565

p38 Rabbit pAb

MBS8542346-01mL 0.1mL
EUR 305

p38 Rabbit pAb

MBS8542346-01mLAF405L 0.1mL(AF405L)
EUR 565

p38 Rabbit pAb

MBS8542346-01mLAF405S 0.1mL(AF405S)
EUR 565

p38 Rabbit pAb

MBS8542346-01mLAF610 0.1mL(AF610)
EUR 565


Conclusion: observational, plasma adiponectin and BMI were inversely. In contrast, the high genetic plasma adiponectin is unlikely to affect BMI and high BMI is not possible genetic influences on plasma adiponectin.