A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma

A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and target in glioma

The Notch signaling network to determine stemness in various tissues and targeting indicates activity on malignant brain cancer by gamma-Secretase inhibitor (GSI) has shown promising preclinical success. However, the translation …