Oxidized low-density lipoprotein (oxLDLs) and oxysterols play a key role in the development of endothelial dysfunction and atherosclerosis. Loss of function of vascular endothelium negative impact vasomotion, cell growth, adhesiveness and barrier function. While for some of these disorders plausible explanation can be provided from a mechanistic standpoint, for many others, the molecular players involved are not known. Caveolae, specific plasma membrane domains, has recently emerged as a target and mediator of oxLDL-induced endothelial dysfunction (ED).

Caveolae and their protein Caveolin-1 related (Cav-1) involved in oxLDLs / LDL transcytosis, especially through the scavenger receptor class B type 1 (SR-B1). Instead, oxLDLs LDL receptor endocytosis mediated by lectin-like oxidized 1 (LOX-1), whose activities depend on intact caveolae system. In addition, LOX-1 regulates expression of Cav-1 and vice versa.

 

On the other hand, oxLDLs may affect the plasma membrane cholesterol content / distribution thus affecting the architecture of caveolae, Cav-1 localization and related signals. Overall, this body of evidence shows that caveolae have both active and passive role in oxLDL-induced EC dysfunction. First as a mediator of lipid uptake and transfer in the subendothelial space, and then, as the target of a change in the composition / plasma membrane lipid dynamics resulting from increased levels of circulating oxLDLs.

Getting a better understanding of how oxLDLs interacts with endothelial cells (EC) and caveolae-mediated signaling pathways modulate, leading to ED, it is important to find new targets of intervention to address atherosclerosis and related clinical entities.

Thiol-based switching mechanism of stress-sensing companion

Thiol-based redox switches evolved as post-translational mechanisms that allow for efficient regulation of individual proteins to quickly respond to sudden environmental changes. While some of the functions of proteins need to be turned off to conserve resources and avoid potentially error-prone process, the protective function becomes important and need to be activated. In this review, we focus on the mechanism of thiol-based activation of the stress-sensing chaperones.

After the exposure to stress, the companion converted into a high-affinity binding platform for ongoing proteins and cells to protect against the accumulation of protein aggregates that are potentially toxic. their chaperone activity independent of ATP, a feature that is very important in conditions of oxidative stress, in which cellular ATP levels drop and canonical ATP-dependent chaperone no longer operate.

Likewise, reductive inactivation and release substrates require recovery of ATP levels, which ensures clients with foldases protein folding ATP-dependent. We will provide an overview on the different strategies that cells evolved to rapidly increase an ATP-independent chaperone on oxidative stress and provide mechanistic insight into how stress conditions used to convert the cellular protein overflow into the holding ATP-independent chaperones.

Both lysosomal integral membrane proteins form a complex MFSD1 and GLMP tight that confer protection from both interaction partners against lysosomal proteolysis. We are here enhanced molecular interactions of the two proteins and found that GLMP luminal domain, but not the transmembrane domain or short cytosolic tail, the inherent protection and mediate interactions with MFSD1.Our data support the finding that the interaction is important for the stabilization of the complex.

These results are supplemented by observations that N-glycosylation of GLMP in general, but not the type N-glycans (high-mannose-type or complex-type) or individual N-glycan chains, it is very important for protection. We observed that the interaction of the two proteins has already begun in the endoplasmic reticulum, and quantitative dependent on one another.

Both proteins can affect otherwise their intracellular trafficking to lysosomes in addition to protection from proteolysis. Finally, we provide evidence that can form homodimers MFSD1 both in vitro and in vivo. Our data repair complex interaction between intimate partner of the lysosomal transporter and accessory subunit.

TREND-DB-atlas transcriptome-wide dynamic landscape of alternative polyadenylation

alternative polyadenylation (APA) extend deep transcriptome complexity. Disruption of the APA can interfere with biological processes, ultimately resulting in disruption destroy. The main challenge in identifying the mechanisms and consequences of APA (and its disturbances) lies in the complexity of the RNA 3 ‘end processing, which involves poorly conserved RNA motif and multi-component complex consisting of more than 50 proteins.

It is more complicated that the RNA 3 ‘end maturation closely associated with transcription, RNA processing and even epigenetic (histone / DNA / RNA) modification. Here, we present TREND-DB , resource cataloging dynamic landscape APA after depletion> 170 proteins involved in various aspects of transcription, gene regulation co- and post-transcriptional, and epigenetic modifications further processing. TREND-DB visualization transcriptome dynamics 3 ‘diversification end (TREND) in a very interactive; APA provides global network maps and allows interrogating genes influenced by APA-specific regulator and vice versa. It also allows the analysis of functional enrichment of specific conditions WHAT affected genes, which show wide biological and clinical relevance in all conditions of RNAi.

DNA antibody
10R-D114b	Fitzgerald	100 ug	EUR 560
Description: Mouse monoclonal DNA antibody

DNA antibody
10C-CR6034M1	Fitzgerald	100 ug	EUR 241
Description: Mouse monoclonal DNA antibody

DNA antibody
10-D20A	Fitzgerald	500 ug	EUR 493
Description: Mouse monoclonal DNA antibody

T7 DNA
310-005	GeneOn	200µg	EUR 82

T7 DNA
310-025	GeneOn	5x200 µg	EUR 225

DNA Antibody
abx023805-02mg	Abbexa	0.2 mg	EUR 648

DNA-Fect
DF37100-1	Neuromics	1 ml	EUR 349

DNA-Fect293
DF37293-1	Neuromics	1 ml	EUR 291

pBR322 DNA
MSD14	Bio Basic	50ug	EUR 152.66

pUC18 DNA
G40-300	GeneOn	50µg	EUR 56

pUC18 DNA
G40-305	GeneOn	5x50µg	EUR 147

DNA-fectamine
DNAF001	Bio Basic	1ml	EUR 278.81

DNA Ligase I (DNA Ligase I) Antibody
abx232431-100ug	Abbexa	100 ug	EUR 481

Mouse Anti-DNA Antibody (DNA) ELISA Kit
abx257816-96tests	Abbexa	96 tests	EUR 746

Taq DNA polymerase (TQ21) , DNA Aptamer, Biotinylated
AD-146-B	Alpha Diagnostics	Custom	Ask for price

Taq DNA polymerase (TQ21) , DNA Aptamer, unlabeled
AD-146-U	Alpha Diagnostics	Custom	Ask for price

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N150	GeneOn	500 units	EUR 102

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N152	GeneOn	5x500 units	EUR 394

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N154	GeneOn	20x500 units	EUR 1525

Human DNA-directed DNA/RNA polymerase mu (POLM)
1-CSB-YP889065HU	Cusabio	EUR 586.00 EUR 299.00 EUR 2172.00 EUR 900.00 EUR 1442.00 EUR 382.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Yeast

Human DNA-directed DNA/RNA polymerase mu (POLM)
1-CSB-BP889065HU	Cusabio	EUR 840.00 EUR 332.00 EUR 2170.00 EUR 1135.00 EUR 1579.00 EUR 470.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Baculovirus

Human DNA-directed DNA/RNA polymerase mu (POLM)
1-CSB-EP889065HU	Cusabio	EUR 505.00 EUR 265.00 EUR 1827.00 EUR 766.00 EUR 1218.00 EUR 335.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in E.coli

Maximo DFS-Plus Taq DNA Polymerase DNA-free
N140	GeneOn	500 units	EUR 50

Maximo DFS-Plus Taq DNA Polymerase DNA-free
N142	GeneOn	5x500 units	EUR 120

Maximo DFS-Plus Taq DNA Polymerase DNA-free
N144	GeneOn	20x500 units	EUR 367

Taq DNA polymerase (TQ21) , DNA Aptamer, FITC labeled
AD-146-F	Alpha Diagnostics	Custom	Ask for price

Human Neutrophil Elastase (DNA I) , DNA Aptamer, Biotinylated
AD-155-B	Alpha Diagnostics	Custom	Ask for price

Human Neutrophil Elastase (DNA I) , DNA Aptamer, unlabeled
AD-155-U	Alpha Diagnostics	Custom	Ask for price

DiscoveryProbe? DNA Damage/DNA Repair-related Compounds Panel
L1007-5	ApexBio	5 mg/well	EUR 5977
Description: A wide range of well-characterized bioactive molecules that covers various targets related to DNA damage/DNA repair, including ATM/ATR, HDAC, and topoisomerase etc. Facilitate your research towards the insights of cancer, genome instability and immune diseases etc.

Recombinant human DNA-directed DNA/RNA polymerase mu
P2815	FN Test	100ug	Ask for price
Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu

DNA PKcs antibody
70R-50261	Fitzgerald	100 ul	EUR 244
Description: Purified Polyclonal DNA PKcs antibody

Taq DNA Polymerase
9001-2500	Biovision		EUR 512

Taq DNA Polymerase
9001-500	Biovision		EUR 191

PFU DNA Polymerase
9003-2500	Biovision		EUR 512

PFU DNA Polymerase
9003-500	Biovision		EUR 180

Laq? DNA Polymerase
9004-2500	Biovision		EUR 610

Laq? DNA Polymerase
9004-500	Biovision		EUR 218

DNA-PK Antibody
AF0550	Affbiotech	200ul	EUR 304
Description: DNA-PK Antibody detects endogenous levels of DNA-PK.

DNA PK Antibody
AF5340	Affbiotech	200ul	EUR 304
Description: DNA PK Antibody detects endogenous levels of total DNA PK.

DNA PK Antibody
ABF5340	Lifescience Market	100 ug	EUR 438

DNA- PK Antibody
ABF0550	Lifescience Market	100 ug	EUR 438

DNA Loading Dye
G030	ABM	6X; 3 x 1.0 ml	EUR 79

Kodaq DNA Polymerase
G498	ABM	250 U (50 ul)	EUR 87

Kodaq DNA Polymerase
G499	ABM	1000 U (200 ul)	EUR 158

anti-DNA PKcs
YF-PA24465	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to DNA PKcs

DNA Assay Kit
Z5030023	Biochain	250 assays	EUR 647
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

DNA PK antibody
20R-1466	Fitzgerald	100 ug	EUR 673
Description: Rabbit polyclonal DNA PK antibody

DNA PKcs antibody
20R-2017	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal DNA PKcs antibody

DNA PKcs antibody
20R-2346	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal DNA PKcs antibody

DNA-PK Antibody
3130-100	Biovision		EUR 338

DNA PKcs antibody
10R-10729	Fitzgerald	100 ug	EUR 381
Description: Mouse monoclonal DNA PKcs antibody

Z-DNA antibody
20-ZS20	Fitzgerald	250 ug	EUR 421
Description: Sheep polyclonal Z-DNA antibody

AceTaq DNA Polymerase
P401-d1	Vazyme	250 U	EUR 136

AceTaq DNA Polymerase
P401-d2	Vazyme	1000 U	EUR 227

AceTaq DNA Polymerase
P401-d3	Vazyme	3000 U	EUR 447

Taq DNA Polymerase
L7051001	Biochain	1000 unit	EUR 195
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Taq DNA Polymerase
L7051200	Biochain	200 unit	EUR 87
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

DNA Storage Solution
LB3401010	Biochain	10 ml	EUR 79
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Ready? DNA Polymerase
M1146-1000	Biovision		EUR 332

Ready? DNA Polymerase
M1146-10000	Biovision		EUR 1066

Ready? DNA Polymerase
M1146-5000	Biovision		EUR 800

Breeze? DNA Polymerase
M1148-1000	Biovision		EUR 1039

Breeze? DNA Polymerase
M1148-250	Biovision		EUR 387

Distant? DNA Polymerase
M1150-1000	Biovision		EUR 686

Distant? DNA Polymerase
M1150-250	Biovision		EUR 278

Advance? DNA Polymerase
M1151-1000	Biovision		EUR 746

Advance? DNA Polymerase
M1151-250	Biovision		EUR 311

Outstretched? DNA Polymerase
M1152-1000	Biovision		EUR 800

Outstretched? DNA Polymerase
M1152-250	Biovision		EUR 332

T4 DNA Polymerase
M1211-100	Biovision		EUR 321

Uracil DNA Glycosylase
M1234-1000	Biovision		EUR 213

Phi29 DNA Polymerase
M1239-1000	Biovision		EUR 311

T4 DNA Polymerase
N101-01	Vazyme	2000 U	EUR 232

DL5000 DNA Marker
MD102-01	Vazyme	250 μl	EUR 107

DL5000 DNA Marker
MD102-02	Vazyme	500 μl	EUR 113

DL15000 DNA Marker
MD103-01	Vazyme	250 μl	EUR 109

DL15000 DNA Marker
MD103-02	Vazyme	500 μl	EUR 115

Taq DNA Polymerase
BA00103	Cusabio	500U	EUR 87
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Mycoplasma DNA Kit
K1416-250	Biovision		EUR 561

Mycoplasma DNA Kit
K1416-50	Biovision		EUR 316

100bp DNA ladder
9K-004-0002	Bio Basic	0.5ml	EUR 217.48

DNA ligase Antibody
20-abx110554	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

EZ-DNA Reagents
BS8202	Bio Basic	100preps	EUR 88.06

Circulating DNA Kit
abx298027-50rxns	Abbexa	50 rxns	EUR 398

2K DNA Marker
20-abx098045	Abbexa	EUR 258.00 EUR 189.00	2.5 ml 500 ul

5K DNA Marker
20-abx098048	Abbexa	EUR 258.00 EUR 189.00	2.5 ml 500 ul

15K DNA Marker
20-abx098049	Abbexa	EUR 272.00 EUR 189.00	2.5 ml 500 ul

1Kb DNA Marker
20-abx098050	Abbexa	EUR 258.00 EUR 189.00	2.5 ml 500 ul

100bp DNA Marker
20-abx098052	Abbexa	EUR 272.00 EUR 189.00	2.5 ml 500 ul

Genomic DNA Kit
20-abx098076	Abbexa	EUR 439.00 EUR 244.00	200 rxns 50 rxns

T4 DNA Ligase
abx098136-10kU	Abbexa	10 kU	EUR 321

T4 DNA Ligase
abx098136-20Ku	Abbexa	20 Ku	EUR 398

DNA Loading Buffer
abx098143-5ml	Abbexa	5 ml	EUR 175

Circulating DNA Kit
abx098870-50rxns	Abbexa	50 rxns	EUR 398

Phage λ-DNA
301-025	GeneOn	500 µg	EUR 102

Phage λ-DNA
301-100	GeneOn	5x500µg	EUR 355

T4 DNA ligase
402-002	GeneOn	400 WEISS UNITS	EUR 63

T4 DNA ligase
402-010	GeneOn	2000 WEISS UNITS	EUR 154

DNA PK Antibody
abx149863-100ug	Abbexa	100 ug	EUR 439

Intercalated DNA Antibody
abx020668-02mg	Abbexa	0.2 mg	EUR 523

DNA Assay Kit
6023	Chondrex	1 kit	EUR 180.5
Description: DNA Assay Kit

Uracil DNA Glycosylase
7-03778	CHI Scientific	2,000U	Ask for price

Uracil DNA Glycosylase
7-03779	CHI Scientific	10,000U	Ask for price

Uracil DNA Glycosylase
7-03780	CHI Scientific	20,000U	Ask for price

DNA polymerase ? (Rat)
10-101	Sceti	20ug	EUR 388
Description: The DNA polymerase ? (Rat) is available in Europe and for worldwide shipping via Gentaur.

DNA polymerase ? (Rat)
10-102	Sceti	100ug	EUR 923
Description: The DNA polymerase ? (Rat) is available in Europe and for worldwide shipping via Gentaur.

DNA Pure Kit
FYG601-100P	Yeastern Biotech	100 Preps	Ask for price

DNA Pure Kit
FYG601-300P	Yeastern Biotech	300 Preps	Ask for price

BIOTAQ DNA Polymerase
BIO-21040	Bioline	500 Units	Ask for price

IMMOLASE DNA Polymerase
BIO-21046	Bioline	250 Units	Ask for price

IMMOLASE DNA Polymerase
BIO-21047	Bioline	500 Units	Ask for price

IMMOLASE DNA Polymerase
BIO-21048	Bioline	5000 Units	Ask for price

ACCUZYME DNA Polymerase
BIO-21051	Bioline	250 Units	Ask for price

ACCUZYME DNA Polymerase
BIO-21052	Bioline	500 Units	Ask for price

BIOTAQ DNA Polymerase
BIO-21060	Bioline	2500 Units	Ask for price

MangoTaq DNA Polymerase
BIO-21078	Bioline	5000 Units	Ask for price

MangoTaq DNA Polymerase
BIO-21082	Bioline	2000 Units	Ask for price

MangoTaq DNA Polymerase
BIO-21083	Bioline	1000 Units	Ask for price

VELOCITY DNA Polymerase
BIO-21098	Bioline	250 Units	Ask for price

VELOCITY DNA Polymerase
BIO-21099	Bioline	500 Units	Ask for price

MyTaq DNA Polymerase
BIO-21105	Bioline	500 units	Ask for price

MyTaq DNA Polymerase
BIO-21105/S	Bioline	Sample	Ask for price

MyTaq DNA Polymerase
BIO-21106	Bioline	2500 units	Ask for price

MyTaq DNA Polymerase
BIO-21107	Bioline	5000 units	Ask for price

MyFi DNA Polymerase
BIO-21117	Bioline	250 Units	Ask for price

MyFi DNA Polymerase
BIO-21117/S	Bioline	Sample	Ask for price

MyFi DNA Polymerase
BIO-21118	Bioline	500 Units	Ask for price

MyFi DNA Polymerase
BIO-21119	Bioline	2500 Units	Ask for price

Ranger DNA Polymerase
BIO-21121	Bioline	250 Units	Ask for price

Ranger DNA Polymerase
BIO-21121/S	Bioline	Sample	Ask for price

Ranger DNA Polymerase
BIO-21122	Bioline	500 Units	Ask for price

Human Genomic DNA
BIO-35025	Bioline	500µl @ 200ng/µl	Ask for price

100bp DNA Marker
D1100-050	GenDepot	50㎍	EUR 165

100bp DNA Marker
D1100-250	GenDepot	5X50㎍	EUR 550

1Kb DNA Marker
D1101-050	GenDepot	50㎍	EUR 131

1Kb DNA Marker
D1101-250	GenDepot	5X50㎍	EUR 300

Human Genomic DNA
X11000	EpiGentek	0.2 ml	Ask for price
Description: reagents widely cited

DNA-PK Antibody
33358-100ul	SAB	100ul	EUR 252

DNA-PK Antibody
33358-50ul	SAB	50ul	EUR 187

Taq DNA Polymerase
BA00104	Bioatlas	1000U	EUR 123
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq DNA Polymerase
BA00105	Bioatlas	2500U	EUR 232
Description: High quality Taq polymerase for different PCR variations and downstream applications.

HotTaq DNA Polymerase
BA00203	Bioatlas	500U	EUR 145
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq DNA Polymerase
BA00204	Bioatlas	1000U	EUR 239
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq DNA Polymerase
BA00205	Bioatlas	2500U	EUR 522
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

RedTaq DNA Polymerase
BA00303	Bioatlas	500U	EUR 123
Description: High quality RedTaq polymerase for different PCR variations and downstream applications.

RedTaq DNA Polymerase
BA00304	Bioatlas	1000U	EUR 196
Description: High quality RedTaq polymerase for different PCR variations and downstream applications.

RedTaq DNA Polymerase
BA00305	Bioatlas	2500U	EUR 413
Description: High quality RedTaq polymerase for different PCR variations and downstream applications.

Pfu DNA Polymerase
BA00503	Bioatlas	500U	EUR 145
Description: High quality Pfu polymerase for different PCR variations and downstream applications.

Pfu DNA Polymerase
BA00504	Bioatlas	1000U	EUR 239
Description: High quality Pfu polymerase for different PCR variations and downstream applications.

Pfu DNA Polymerase
BA00505	Bioatlas	2500U	EUR 522
Description: High quality Pfu polymerase for different PCR variations and downstream applications.

ClearSight DNA Stain
BH40501	Bioatlas	1ml	EUR 103
Description: For DNA staining and vizualization.

Taq DNA polymerase
BT10101	Bioatlas	500U	EUR 80
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq DNA polymerase
BT10102	Bioatlas	1000U	EUR 109
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq DNA polymerase
BT10103	Bioatlas	2000U	EUR 167
Description: High quality Taq polymerase for different PCR variations and downstream applications.

HotTaq DNA polymerase
BT10201	Bioatlas	500U	EUR 120
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq DNA polymerase
BT10202	Bioatlas	1000U	EUR 190
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

EZ-DNA Reagents
SK8201	Bio Basic	100preps	EUR 93.5

Pfu DNA Polymerase
S116	GeneOn	1x250 units	EUR 76

Pfu DNA Polymerase
S117	GeneOn	2x250 units	EUR 94

Pfu DNA Polymerase
S118	GeneOn	10x250 units	EUR 303

Bst DNA Polymerase
S600	GeneOn	2000 U	EUR 107

Green-DNA Dye
SB2040	Bio Basic	100UL, 100UL	EUR 67.4

pUC 18 DNA
MSD15	Bio Basic	50ug	EUR 122.21

pUC 19 DNA
MSD16	Bio Basic	50ug	EUR 113.51

pUC 57 DNA
MSD17	Bio Basic	50ug	EUR 113.51

DNA Concentrator Kit
P-1006	EpiGentek	100 Samples	EUR 253
Description: Ask the seller for details

Calf thymus DNA
HY-109517	MedChemExpress	100mg	EUR 1910

DNA Sample Diluent
D006-100	Cygnus Technologies	100 ml	EUR 373
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

DNA Sample Diluent
D006-1000	Cygnus Technologies	1000 ml	EUR 1167
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

DNA Sample Diluent
D006-500	Cygnus Technologies	500 ml	EUR 726
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

DNA Precipitation Buffer
D106	Cygnus Technologies	55 ml	EUR 175
Description: DNA Precipitation Buffer by Cygnus Technologies is available in Europe via Gentaur.

Human DNA Concentrate
D162	Cygnus Technologies	1 ml	EUR 506
Description: Human DNA Concentrate by Cygnus Technologies is available in Europe via Gentaur.

E.coli DNA Concentrate
D412	Cygnus Technologies	1 ml	EUR 542
Description: E.coli DNA Concentrate by Cygnus Technologies is available in Europe via Gentaur.

CHO DNA Concentrate
D552	Cygnus Technologies	1 ml	EUR 542
Description: CHO DNA Concentrate by Cygnus Technologies is available in Europe via Gentaur.

CHO DNA Concentrate
D556	Cygnus Technologies	120 ul	EUR 469
Description: CHO DNA Concentrate by Cygnus Technologies is available in Europe via Gentaur.

Kinetoplast DNA (catenated)
TG2013-1	TopoGen	25 ug	EUR 268

Kinetoplast DNA (catenated)
TG2013-2	TopoGen	50 ug	EUR 380

Kinetoplast DNA (catenated)
TG2013-3	TopoGen	250 ug	EUR 1052

DNA PKcs Antibody
48923-100ul	SAB	100ul	EUR 333

DNA PKcs Antibody
48923-50ul	SAB	50ul	EUR 239

Sapphire Baculovirus DNA
ABP-BVD-10001	Allele Biotech	15 µg (10 rxns)	Ask for price

Uracil DNA Glycosilase
RP-1470	Alpha Diagnostics	2000 IU	EUR 286

n-DNA-Ab/ Rat n- DNA- Ab ELISA Kit
ELA-E1126r	Lifescience Market	96 Tests	EUR 886

Human Single Stranded DNA (SS-DNA) Antibody ELISA Kit
abx364935-96tests	Abbexa	96 tests	EUR 511

Human Double Stranded DNA (DS-DNA) Antibody ELISA Kit
abx364947-96tests	Abbexa	96 tests	EUR 511

DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Antibody
abx232474-100ug	Abbexa	100 ug	EUR 509

DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Antibody
20-abx008825	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PK) Antibody
20-abx013061	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

ds-DNA Double-stranded DNA Ab IgG ELISA test
114	Biobase	96T/Box	Ask for price
Description: ELISA based test for quantitative detection of ds-DNA Double-stranded DNA Ab IgG

ss-DNA (Single-stranded DNA Antibody IgG) ELISA test
51	Biobase	96T/Box	Ask for price
Description: ELISA based test for quantitative detection of ss-DNA (Single-stranded DNA Antibody IgG)

Human Neutrophil Elastase (DNA I) , DNA Aptamer, FITC labeled
AD-155-F	Alpha Diagnostics	Custom	Ask for price

Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (50ug Relaxed DNA + 100u Gyrase)
TG2000G-1KIT	TopoGen	100 assays	EUR 380

Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (250ug Relaxed DNA + 500u Gyrase)
TG2000G-3KIT	TopoGen	500 assays	EUR 985

Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (500ug Relaxed DNA + 1000u Gyrase)
TG2000G-5KIT	TopoGen	1000 assays	EUR 1612

Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (1mg Relaxed DNA + 2000u Gyrase)
TG2000G-7KIT	TopoGen	2000 assays	EUR 2844

Human DNA- directed DNA/ RNA polymerase mu, POLM ELISA KIT
ELI-09243h	Lifescience Market	96 Tests	EUR 824

Mouse DNA- directed DNA/RNA polymerase mu, Polm ELISA KIT
ELI-32836m	Lifescience Market	96 Tests	EUR 865

2K Plus DNA Marker (8 linear double-stranded DNA bands)
20-abx098046	Abbexa	EUR 258.00 EUR 189.00	2.5 ml 500 ul

2K Plus DNA Marker (9 linear double-stranded DNA bands)
20-abx098047	Abbexa	EUR 258.00 EUR 189.00	2.5 ml 500 ul

100bp Plus DNA Marker (12 linear double-stranded DNA bands)
20-abx098053	Abbexa	EUR 272.00 EUR 189.00	2.5 ml 500 ul

Implementation of the UCSC Genome Browser provides additional customized layer of gene regulation accounting for individual transcript isoforms (eg, epigenetic, miRNA-binding sites and RNA-binding protein). TREND-DB that encourages APA outlines roles for various biological program, including potential disease mechanisms, and help identify potential diagnostic and therapeutic them.