Oxidized low-density lipoprotein (oxLDLs) and oxysterols play a key role in the development of endothelial dysfunction and atherosclerosis. Loss of function of vascular endothelium negative impact vasomotion, cell growth, adhesiveness and barrier function. While for some of these disorders plausible explanation can be provided from a mechanistic standpoint, for many others, the molecular players involved are not known. Caveolae, specific plasma membrane domains, has recently emerged as a target and mediator of oxLDL-induced endothelial dysfunction (ED).

Caveolae and their protein Caveolin-1 related (Cav-1) involved in oxLDLs / LDL transcytosis, especially through the scavenger receptor class B type 1 (SR-B1). Instead, oxLDLs LDL receptor endocytosis mediated by lectin-like oxidized 1 (LOX-1), whose activities depend on intact caveolae system. In addition, LOX-1 regulates expression of Cav-1 and vice versa.

 

On the other hand, oxLDLs may affect the plasma membrane cholesterol content / distribution thus affecting the architecture of caveolae, Cav-1 localization and related signals. Overall, this body of evidence shows that caveolae have both active and passive role in oxLDL-induced EC dysfunction. First as a mediator of lipid uptake and transfer in the subendothelial space, and then, as the target of a change in the composition / plasma membrane lipid dynamics resulting from increased levels of circulating oxLDLs.

Getting a better understanding of how oxLDLs interacts with endothelial cells (EC) and caveolae-mediated signaling pathways modulate, leading to ED, it is important to find new targets of intervention to address atherosclerosis and related clinical entities.

Thiol-based switching mechanism of stress-sensing companion

Thiol-based redox switches evolved as post-translational mechanisms that allow for efficient regulation of individual proteins to quickly respond to sudden environmental changes. While some of the functions of proteins need to be turned off to conserve resources and avoid potentially error-prone process, the protective function becomes important and need to be activated. In this review, we focus on the mechanism of thiol-based activation of the stress-sensing chaperones.

After the exposure to stress, the companion converted into a high-affinity binding platform for ongoing proteins and cells to protect against the accumulation of protein aggregates that are potentially toxic. their chaperone activity independent of ATP, a feature that is very important in conditions of oxidative stress, in which cellular ATP levels drop and canonical ATP-dependent chaperone no longer operate.

Likewise, reductive inactivation and release substrates require recovery of ATP levels, which ensures clients with foldases protein folding ATP-dependent. We will provide an overview on the different strategies that cells evolved to rapidly increase an ATP-independent chaperone on oxidative stress and provide mechanistic insight into how stress conditions used to convert the cellular protein overflow into the holding ATP-independent chaperones.

Both lysosomal integral membrane proteins form a complex MFSD1 and GLMP tight that confer protection from both interaction partners against lysosomal proteolysis. We are here enhanced molecular interactions of the two proteins and found that GLMP luminal domain, but not the transmembrane domain or short cytosolic tail, the inherent protection and mediate interactions with MFSD1.Our data support the finding that the interaction is important for the stabilization of the complex.

These results are supplemented by observations that N-glycosylation of GLMP in general, but not the type N-glycans (high-mannose-type or complex-type) or individual N-glycan chains, it is very important for protection. We observed that the interaction of the two proteins has already begun in the endoplasmic reticulum, and quantitative dependent on one another.

Both proteins can affect otherwise their intracellular trafficking to lysosomes in addition to protection from proteolysis. Finally, we provide evidence that can form homodimers MFSD1 both in vitro and in vivo. Our data repair complex interaction between intimate partner of the lysosomal transporter and accessory subunit.

TREND-DB-atlas transcriptome-wide dynamic landscape of alternative polyadenylation

alternative polyadenylation (APA) extend deep transcriptome complexity. Disruption of the APA can interfere with biological processes, ultimately resulting in disruption destroy. The main challenge in identifying the mechanisms and consequences of APA (and its disturbances) lies in the complexity of the RNA 3 ‘end processing, which involves poorly conserved RNA motif and multi-component complex consisting of more than 50 proteins.

It is more complicated that the RNA 3 ‘end maturation closely associated with transcription, RNA processing and even epigenetic (histone / DNA / RNA) modification. Here, we present TREND-DB , resource cataloging dynamic landscape APA after depletion> 170 proteins involved in various aspects of transcription, gene regulation co- and post-transcriptional, and epigenetic modifications further processing. TREND-DB visualization transcriptome dynamics 3 ‘diversification end (TREND) in a very interactive; APA provides global network maps and allows interrogating genes influenced by APA-specific regulator and vice versa. It also allows the analysis of functional enrichment of specific conditions WHAT affected genes, which show wide biological and clinical relevance in all conditions of RNAi.

pUC18 DNA
G40-300	GeneOn	50µg	EUR 67.2

pUC18 DNA
G40-305	GeneOn	5x50µg	EUR 176.4

DNA-Fect
DF37100-1	Neuromics	1 ml	EUR 418.8

pBR322 DNA
MSD14	Bio Basic	50ug	EUR 183.19

DNA Primase
E8ER1907-59	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

DNA Ligase I (DNA Ligase I) Antibody
abx232431-100ug	Abbexa	100 ug	EUR 577.2

DNA antibody
10-D20A	Fitzgerald	500 ug	EUR 591.6
Description: Mouse monoclonal DNA antibody

DNA antibody
10C-CR6034M1	Fitzgerald	100 ug	EUR 289.2
Description: Mouse monoclonal DNA antibody

DNA antibody
10R-D114b	Fitzgerald	100 ug	EUR 672
Description: Mouse monoclonal DNA antibody

DNA Antibody
abx023805-02mg	Abbexa	0.2 mg	EUR 777.6

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N150	GeneOn	500 units	EUR 122.4

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N152	GeneOn	5x500 units	EUR 472.8

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)
N154	GeneOn	20x500 units	EUR 1830

Activated DNA
80605	BPS Bioscience	500 µL	EUR 125
Description: Activated DNA for PARP assay, for use with BPS's assay kits for PARPs 1, 2, 3, and 6. PARP1 Chemiluminescent Assay Kit, #80551 ; PARP2 Chemiluminescent Assay Kit, #80552; PARP3 Chemiluminescent Assay Kit, #80553; PARP6 Chemiluminescent Assay Kit, #80556; PARP2 Homogeneous Assay Kit, #80702

DNA-Fect293
DF37293-1	Neuromics	1 ml	EUR 349.2

DNA Polymerase
ABD3082	Lifescience Market	100 ug	EUR 525.6

DNA Polymerase
ABF5235	Lifescience Market	100 ug	EUR 525.6

DNA-fectamine
DNAF001	Bio Basic	1ml	EUR 334.57

Taq DNA polymerase (TQ21) , DNA Aptamer, unlabeled
AD-146-U	Alpha Diagnostics	Custom	Ask for price

DiscoveryProbe™ DNA Damage/DNA Repair Library
L1033-.096	ApexBio	100uL/well(10 mM solution),96 Well Deep Well Plate	EUR 6980
Description: A unique collection of 481 DNA Damage/DNA repair-related compounds for DNA damage/DNA repair research.

Taq DNA polymerase (TQ21) , DNA Aptamer, Biotinylated
AD-146-B	Alpha Diagnostics	Custom	Ask for price

Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (1mg Relaxed DNA + 2000u Gyrase)
TG2000G-7KIT	TopoGen	2000 assays	EUR 3412.8

Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (500ug Relaxed DNA + 1000u Gyrase)
TG2000G-5KIT	TopoGen	1000 assays	EUR 1934.4

Human DNA-directed DNA/RNA polymerase mu (POLM)
1-CSB-BP889065HU	Cusabio	EUR 1008.00 EUR 398.40 EUR 2604.00 EUR 1362.00 EUR 1894.80 EUR 564.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Baculovirus

Human DNA-directed DNA/RNA polymerase mu (POLM)
1-CSB-YP889065HU	Cusabio	EUR 703.20 EUR 358.80 EUR 2606.40 EUR 1080.00 EUR 1730.40 EUR 458.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in Yeast

Human DNA-directed DNA/RNA polymerase mu (POLM)
1-CSB-EP889065HU	Cusabio	EUR 606.00 EUR 318.00 EUR 2192.40 EUR 919.20 EUR 1461.60 EUR 402.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) expressed in E.coli

Maximo DFS-Plus Taq DNA Polymerase DNA-free
N140	GeneOn	500 units	EUR 60

Maximo DFS-Plus Taq DNA Polymerase DNA-free
N142	GeneOn	5x500 units	EUR 144

Maximo DFS-Plus Taq DNA Polymerase DNA-free
N144	GeneOn	20x500 units	EUR 440.4

Taq DNA polymerase (TQ21) , DNA Aptamer, FITC labeled
AD-146-F	Alpha Diagnostics	Custom	Ask for price

pUC 18 DNA
MSD15	Bio Basic	50ug	EUR 146.65

pUC 19 DNA
MSD16	Bio Basic	50ug	EUR 136.21

pUC 57 DNA
MSD17	Bio Basic	50ug	EUR 136.21

Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (50ug Relaxed DNA + 100u Gyrase)
TG2000G-1KIT	TopoGen	100 assays	EUR 456

Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (250ug Relaxed DNA + 500u Gyrase)
TG2000G-3KIT	TopoGen	500 assays	EUR 1182

Human Neutrophil Elastase (DNA I) , DNA Aptamer, unlabeled
AD-155-U	Alpha Diagnostics	Custom	Ask for price

Recombinant human DNA-directed DNA/RNA polymerase mu
P2815	FN Test	100ug	Ask for price
Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu

DNA Pure Kit
FYG601-100P	Yeastern Biotech	100 Preps	Ask for price

DNA Pure Kit
FYG601-300P	Yeastern Biotech	300 Preps	Ask for price

Taq Plus DNA
enz-309	ProSpec Tany	250U	EUR 60
Description: Recombinant Taq Plus DNA Polymerase

Mouse Anti-DNA Antibody (DNA) ELISA Kit
abx257816-96tests	Abbexa	96 tests	EUR 895.2

Human Neutrophil Elastase (DNA I) , DNA Aptamer, Biotinylated
AD-155-B	Alpha Diagnostics	Custom	Ask for price

2K DNA Marker
20-abx098045	Abbexa	EUR 309.60 EUR 226.80	2.5 ml 500 ul

5K DNA Marker
20-abx098048	Abbexa	EUR 309.60 EUR 226.80	2.5 ml 500 ul

T4 DNA Ligase
abx098136-10kU	Abbexa	10 kU	EUR 385.2

T4 DNA Ligase
abx098136-20Ku	Abbexa	20 Ku	EUR 477.6

Phage λ-DNA
301-025	GeneOn	500 µg	EUR 122.4

Phage λ-DNA
301-100	GeneOn	5x500µg	EUR 426

T4 DNA ligase
402-002	GeneOn	400 WEISS UNITS	EUR 75.6

T4 DNA ligase
402-010	GeneOn	2000 WEISS UNITS	EUR 184.8

DNA Assay Kit
6023	Chondrex	1 kit	EUR 216.6
Description: DNA Assay Kit

DNA Assay Kit
Z5030023	Biochain	250 assays	EUR 636

DNA Ligase IV
E8ET1705-77	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

DNA Ligase I
E8ET7107-14	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

T4 DNA Ligase
RK21501	Abclonal	80000U	EUR 10

15K DNA Marker
20-abx098049	Abbexa	EUR 326.40 EUR 226.80	2.5 ml 500 ul

1Kb DNA Marker
20-abx098050	Abbexa	EUR 309.60 EUR 226.80	2.5 ml 500 ul

1Kb DNA Marker
D1101-050	GenDepot	50㎍	EUR 157.2

1Kb DNA Marker
D1101-250	GenDepot	5X50㎍	EUR 360

DNA LADDER (1KB)
IB01351	IBI Scientific	50uG/500uL	EUR 61.65
Description: [FR]

Taq DNA Ligase
RK20502	Abclonal	2000U	EUR 105

DiscoveryProbe? DNA Damage/DNA Repair-related Compounds Panel
L1007-5	ApexBio	5 mg/well	EUR 7172.4
Description: A wide range of well-characterized bioactive molecules that covers various targets related to DNA damage/DNA repair, including ATM/ATR, HDAC, and topoisomerase etc. Facilitate your research towards the insights of cancer, genome instability and immune diseases etc.

Genomic DNA Kit
20-abx098076	Abbexa	EUR 526.80 EUR 292.80	200 rxns 50 rxns

DNA PK Antibody
abx149863-100ug	Abbexa	100 ug	EUR 526.8

DNA PK antibody
20R-1466	Fitzgerald	100 ug	EUR 807.6
Description: Rabbit polyclonal DNA PK antibody

DNA- PK Antibody
ABF0550	Lifescience Market	100 ug	EUR 525.6

DNA PK Antibody
ABF5340	Lifescience Market	100 ug	EUR 525.6

DNA Loading Dye
G030	ABM	6X; 3 x 1.0 ml	EUR 94.8

Calf thymus DNA
HY-109517	MedChemExpress	100mg	EUR 2292

DNA LADDER (100bp)
IB01301	IBI Scientific	50uG/500uL	EUR 59.65
Description: [FR]

DNA LADDER (100bp)
IB01302	IBI Scientific	50uG/500uL	EUR 56.1
Description: (NO LOADING DYE) [FR]

GENOMIC DNA KIT
IB47250	IBI Scientific	2 X 96 PREP KIT	EUR 759.68

GENOMIC DNA KIT
IB47251	IBI Scientific	4 X 96 PREP KIT	EUR 1464.04

GENOMIC DNA KIT
IB47252	IBI Scientific	10 X 96 PREP KIT	EUR 3254.61

DNA PK Antibody
AF5340-100ul	Affinity Biosciences	100ul	EUR 280

DNA PK Antibody
AF5340-200ul	Affinity Biosciences	200ul	EUR 350

DNA PK Antibody
AF5340	Affinity Biosciences	100ul	EUR 280
Description: Human,Mouse

DNA PK Antibody
E18-5340-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

DNA PK Antibody
E18-5340-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

E.coli DNA Ligase
RK20501	Abclonal	1000U	EUR 20.5

100bp DNA Marker
20-abx098052	Abbexa	EUR 326.40 EUR 226.80	2.5 ml 500 ul

100bp DNA ladder
9K-004-0002	Bio Basic	0.5ml	EUR 260.98

100bp DNA Marker
D1100-050	GenDepot	50㎍	EUR 198

100bp DNA Marker
D1100-250	GenDepot	5X50㎍	EUR 660

DNA-PKcs/PRKDC
E8M1204-6	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

DNA pol Antibody
E18-9055-1	EnoGene	50ug/50ul	EUR 145
Description: Available in various conjugation types.

DNA pol Antibody
E18-9055-2	EnoGene	100ug/100ul	EUR 225
Description: Available in various conjugation types.

DNA PKcs antibody
10R-10729	Fitzgerald	100 ug	EUR 457.2
Description: Mouse monoclonal DNA PKcs antibody

DNA PKcs antibody
20R-2017	Fitzgerald	50 ug	EUR 337.2
Description: Rabbit polyclonal DNA PKcs antibody

DNA PKcs antibody
20R-2346	Fitzgerald	50 ug	EUR 337.2
Description: Rabbit polyclonal DNA PKcs antibody

DNA-PK Antibody
3130-100	Biovision	each	EUR 405.6

Human Genomic DNA
BIO-35025	Bioline	500µl @ 200ng/µl	Ask for price

DNA PKcs antibody
70R-50261	Fitzgerald	100 ul	EUR 292.8
Description: Purified Polyclonal DNA PKcs antibody

DNA-PK Antibody
33358-100ul	SAB	100ul	EUR 302.4

DNA-PK Antibody
33358-50ul	SAB	50ul	EUR 224.4

DNA PKcs Antibody
48923-100ul	SAB	100ul	EUR 399.6

DNA PKcs Antibody
48923-50ul	SAB	50ul	EUR 286.8

T4 DNA Polymerase
N101-01	Vazyme	2000 U	EUR 278.4

T4 DNA Polymerase
M1211-100	Biovision	each	EUR 385.2

DL5000 DNA Marker
MD102-01	Vazyme	250 μl	EUR 128.4

DL5000 DNA Marker
MD102-02	Vazyme	500 μl	EUR 135.6

DNA-PK Antibody
AF0550-100ul	Affinity Biosciences	100ul	EUR 280

DNA-PK Antibody
AF0550-200ul	Affinity Biosciences	200ul	EUR 350

DNA polymerase mu
E8ER1907-58	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

DNA-PK Antibody
AF6631-100ul	Affinity Biosciences	100ul	EUR 280

DNA-PK Antibody
AF6631-200ul	Affinity Biosciences	200ul	EUR 350

DNA-PK Antibody
AF6631	Affinity Biosciences	100ul	EUR 280
Description: Human,Mouse

DNA-PK Antibody
AF0550	Affinity Biosciences	100ul	EUR 280
Description: Human,Mouse

Human Genomic DNA
X11000	EpiGentek	Ask for price EUR 235.40	0.2 ml 0.2 ml

DNA-PK Antibody
E11-0174C	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

DNA-PK Antibody
E11-0421B	EnoGene	100μg	EUR 225
Description: Available in various conjugation types.

DNA-PK Antibody
E11-0906B	EnoGene	100μg	EUR 225
Description: Available in various conjugation types.

DNA-PK Antibody
E11-0908B	EnoGene	100μg	EUR 225
Description: Available in various conjugation types.

DNA-PK Antibody
E11-0909B	EnoGene	100μg	EUR 225
Description: Available in various conjugation types.

DNA-PK Antibody
E033358	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

DNA-PK Antibody
E18-0550-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

DNA-PK Antibody
E18-0550-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

DNA Loading Buffer
abx098143-5ml	Abbexa	5 ml	EUR 210

DNA polymerase ? (Rat)
10-101	Sceti	20ug	EUR 465.6
Description: The DNA polymerase ? (Rat) is available in Europe and for worldwide shipping via Gentaur.

DNA polymerase ? (Rat)
10-102	Sceti	100ug	EUR 1107.6
Description: The DNA polymerase ? (Rat) is available in Europe and for worldwide shipping via Gentaur.

Taq DNA Polymerase
BA00103	Cusabio	500U	EUR 104.4
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq DNA Polymerase
BA00104	Bioatlas	1000U	EUR 147.6
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq DNA Polymerase
BA00105	Bioatlas	2500U	EUR 278.4
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Pfu DNA Polymerase
BA00503	Bioatlas	500U	EUR 174
Description: High quality Pfu polymerase for different PCR variations and downstream applications.

Pfu DNA Polymerase
BA00504	Bioatlas	1000U	EUR 286.8
Description: High quality Pfu polymerase for different PCR variations and downstream applications.

Pfu DNA Polymerase
BA00505	Bioatlas	2500U	EUR 626.4
Description: High quality Pfu polymerase for different PCR variations and downstream applications.

Taq DNA polymerase
BT10101	Bioatlas	500U	EUR 96
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq DNA polymerase
BT10102	Bioatlas	1000U	EUR 130.8
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq DNA polymerase
BT10103	Bioatlas	2000U	EUR 200.4
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq DNA Polymerase
9001-2500	Biovision	each	EUR 614.4

Taq DNA Polymerase
9001-500	Biovision	each	EUR 229.2

PFU DNA Polymerase
9003-2500	Biovision	each	EUR 614.4

PFU DNA Polymerase
9003-500	Biovision	each	EUR 216

Laq? DNA Polymerase
9004-2500	Biovision	each	EUR 732

Laq? DNA Polymerase
9004-500	Biovision	each	EUR 261.6

DNA Cleared Plasma
DCP100A-1	SBI	100 ml	EUR 417

DNA Sample Diluent
D006-100	Cygnus Technologies	100 ml	EUR 447.6
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

DNA Sample Diluent
D006-1000	Cygnus Technologies	1000 ml	EUR 1400.4
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

DNA Sample Diluent
D006-500	Cygnus Technologies	500 ml	EUR 871.2
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Taq DNA Polymerase
L7051001	Biochain	1000 unit	EUR 159

Taq DNA Polymerase
L7051200	Biochain	200 unit	EUR 41

DL15000 DNA Marker
MD103-01	Vazyme	250 μl	EUR 130.8

DL15000 DNA Marker
MD103-02	Vazyme	500 μl	EUR 138

Mycoplasma DNA Kit
K1416-250	Biovision	each	EUR 673.2

Mycoplasma DNA Kit
K1416-50	Biovision	each	EUR 379.2

Pfu DNA Polymerase
S116	GeneOn	1x250 units	EUR 91.2

Pfu DNA Polymerase
S117	GeneOn	2x250 units	EUR 112.8

Pfu DNA Polymerase
S118	GeneOn	10x250 units	EUR 363.6

Bst DNA Polymerase
S600	GeneOn	2000 U	EUR 128.4

Pfu DNA Polymerase
enz-265	ProSpec Tany	100U	EUR 145
Description: Recombinant Pfu DNA Polymerase

100 bp DNA Ladder
M1158-500	Biovision	each	EUR 333.6

100 bp DNA Ladder
MD104-01	Vazyme	250 μl	EUR 132

100 bp DNA Ladder
MD104-02	Vazyme	500 μl	EUR 139.2

100 bp DNA Ladder
RM19007	Abclonal	500μL	EUR 138

DNA ligase Antibody
20-abx110554	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Circulating DNA Kit
abx098870-50rxns	Abbexa	50 rxns	EUR 477.6

MyFi DNA Polymerase
BIO-21117	Bioline	250 Units	Ask for price

MyFi DNA Polymerase
BIO-21117/S	Bioline	Sample	Ask for price

MyFi DNA Polymerase
BIO-21118	Bioline	500 Units	Ask for price

MyFi DNA Polymerase
BIO-21119	Bioline	2500 Units	Ask for price

CHO DNA Concentrate
D552	Cygnus Technologies	1 ml	EUR 650.4
Description: CHO DNA Concentrate by Cygnus Technologies is available in Europe via Gentaur.

CHO DNA Concentrate
D556	Cygnus Technologies	120 ul	EUR 562.8
Description: CHO DNA Concentrate by Cygnus Technologies is available in Europe via Gentaur.

Circulating DNA Kit
abx298027-50rxns	Abbexa	50 rxns	EUR 477.6

DNA-PKcs Antibody
R31076	NSJ Bioreagents	100 ug	EUR 356.15
Description: Protein Kinase DNA-Activated catalytic subunit, also called DNAPK, HYRC1, p350 or DNPK1, is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. Satoh et al.(1997) mapped the MCM4 gene to 8q11.2 by FISH. Based on the close proximity of the PRKDC and MCM4 genes, it was assumed that the PRKDC gene also maps to this location. Anderson and Lees-Miller(1992) noted that DNA-PKcs had been shown in vitro to phosphorylate several transcription factors, suggesting that it functions in cell homeostasis by modulating transcription. Daniel et al.(1999) demonstrated that the DNA-PKcs protein participates in retroviral DNA integration, which is catalyzed by the viral protein integrase.

DNA Destaining Bags
10550021-1	Bio-WORLD	25 Bag (s)	EUR 85.81

DNA Polymerase beta
E8ET1705-12	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

DNA-PKcs Antibody
E2200618	EnoGene	100ug	EUR 255
Description: Available in various conjugation types.

ClearSight DNA Stain
BH40501	Bioatlas	1ml	EUR 123.6
Description: For DNA staining and vizualization.

MyTaq DNA Polymerase
BIO-21105	Bioline	500 units	Ask for price

MyTaq DNA Polymerase
BIO-21105/S	Bioline	Sample	Ask for price

MyTaq DNA Polymerase
BIO-21106	Bioline	2500 units	Ask for price

MyTaq DNA Polymerase
BIO-21107	Bioline	5000 units	Ask for price

E.coli DNA Concentrate
D412	Cygnus Technologies	1 ml	EUR 650.4
Description: E.coli DNA Concentrate by Cygnus Technologies is available in Europe via Gentaur.

DNA Storage Solution
LB3401010	Biochain	10 ml	EUR 34

DNA Concentrator Kit
P-1006	EpiGentek	EUR 303.60 EUR 90.20 EUR 171.60	100 Samples 50 Samples 100 Samples

Ready? DNA Polymerase
M1146-1000	Biovision	each	EUR 398.4

Ready? DNA Polymerase
M1146-10000	Biovision	each	EUR 1279.2

Ready? DNA Polymerase
M1146-5000	Biovision	each	EUR 960

Phi29 DNA Polymerase
M1239-1000	Biovision	each	EUR 373.2

Kodaq DNA Polymerase
G498	ABM	250 U (50 ul)	EUR 104.4

Kodaq DNA Polymerase
G499	ABM	1000 U (200 ul)	EUR 189.6

DNA polymerase delta
E8ER1907-56	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

phi29 DNA Polymerase
RK21002	Abclonal	1250U	EUR 4

HotTaq DNA Polymerase
BA00203	Bioatlas	500U	EUR 174
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq DNA Polymerase
BA00204	Bioatlas	1000U	EUR 286.8
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq DNA Polymerase
BA00205	Bioatlas	2500U	EUR 626.4
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

RedTaq DNA Polymerase
BA00303	Bioatlas	500U	EUR 147.6
Description: High quality RedTaq polymerase for different PCR variations and downstream applications.

RedTaq DNA Polymerase
BA00304	Bioatlas	1000U	EUR 235.2
Description: High quality RedTaq polymerase for different PCR variations and downstream applications.

RedTaq DNA Polymerase
BA00305	Bioatlas	2500U	EUR 495.6
Description: High quality RedTaq polymerase for different PCR variations and downstream applications.

BIOTAQ DNA Polymerase
BIO-21040	Bioline	500 Units	Ask for price

BIOTAQ DNA Polymerase
BIO-21060	Bioline	2500 Units	Ask for price

Ranger DNA Polymerase
BIO-21121	Bioline	250 Units	Ask for price

Ranger DNA Polymerase
BIO-21121/S	Bioline	Sample	Ask for price

Ranger DNA Polymerase
BIO-21122	Bioline	500 Units	Ask for price

HotTaq DNA polymerase
BT10201	Bioatlas	500U	EUR 144
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq DNA polymerase
BT10202	Bioatlas	1000U	EUR 228
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

Human DNA Concentrate
D162	Cygnus Technologies	1 ml	EUR 607.2
Description: Human DNA Concentrate by Cygnus Technologies is available in Europe via Gentaur.

AceTaq DNA Polymerase
P401-d1	Vazyme	250 U	EUR 163.2

AceTaq DNA Polymerase
P401-d2	Vazyme	1000 U	EUR 272.4

AceTaq DNA Polymerase
P401-d3	Vazyme	3000 U	EUR 536.4

Implementation of the UCSC Genome Browser provides additional customized layer of gene regulation accounting for individual transcript isoforms (eg, epigenetic, miRNA-binding sites and RNA-binding protein). TREND-DB that encourages APA outlines roles for various biological program, including potential disease mechanisms, and help identify potential diagnostic and therapeutic them.