The Notch signaling network to determine stemness in various tissues and targeting indicates activity on malignant brain cancer by gamma-Secretase inhibitor (GSI) has shown promising preclinical success. However, the translation of the remains clinically challenging because the side effects of severe toxicity and the emergence of resistance to therapy. Better anti-Notch therapies directed, particularly directed against the tumor promoting receptor Notch 1 signaling framework, and biomarkers that predict response to therapy of the highest clinical needs.
We assessed several patient dataset to investigate the clinical relevance of activation of Notch1 and possible differential distribution between molecular subtypes in brain cancer. We functionally assess the biological effects of the first-in-man is tested blocking antibody against the receptor Notch1 (brontictuzumab, BRON) in the collection of stem-like cell model of glioma (GSC) and compared the effect of genetic inhibition of Notch1 and pharmacological classic Notch inhibitor treatment using gamma-Secretase MRK003 inhibitor.
We also assess the effect on winged (NTB) stem cell activation signal, which includes interrogation NTB models genetic inhibition. calculated transcription Notch pathway activation score we upregulated in neural stem cells, as compared to astrocytes; as well as in GSCs, compared with differentiated glioblastoma cells.
In addition, the signature Notch is a glioblastoma clinical prediction on the discovery and validation of our patient cohort. Notch signature significantly elevated in tumors with mutant genomes IDH1 and tumors without 1p and 19q co-deletion. In GSCs with increased expression of Notch1, BRON treatment block gene transcription Notch pathway target Hes1 / Hey1, significantly reducing the amount of cleaved Notch1 receptor protein and cause a significant decrease in cellular invasion. Benchmarking this phenotype to that observed with the genetic inhibition of Notch1 in the appropriate cell model did result in a higher reduction of cell invasion under chemotherapy.
BRON treatment of the signs resulting from upregulation of winged (NTB) stem cell activity signals, and vice versa, due to blockage of WNT signaling induced expression of Notch target genes in our model. We extend the list of evidence that elevated expression of Notch signaling biomarker signature stating the prevalence of stem cells and clinically useful for predicting negative in glioblastoma. By using functional tests, we first validated in human Notch1 receptor-specific antibodies were tested as promising candidates in the context of neuro-oncology and biomarker panel proposes to predict the durability and therapeutic success of these treatment options. We note that the observed phenotype appears to be partial because of Notch1 blockage and lead candidate to target signal activation off.
Further studies addressing the possible emergence of resistance to therapy because NTB need activation will be done. We further validated our 3D disease modeling technology to be a benefit for development projects.
Protein arginine methyltransferase 5 pICln promote androgen receptor-dependent transcription in castration-resistant prostate cancer
The majority of prostate cancer therapy aims to inhibit the androgen receptor (AR) signaling. However, AR reactivation certainly encourage the development of disease castration-resistant prostate cancer (CRPC). Here we show that the protein arginine methyltransferase 5 (PRMT5) serves as an epigenetic activator of transcription AR in CRPC, requires cooperation with methylosome pICln subunit. In vitro and in xenograft tumors in mice, targeting PRMT5 or pICln pressed CRPC cell growth.
Full-length AR and AR-V7 good transcriptional activation required PRMT5 and pICln but not MEP50. This activation of transcription-mediated accompanied by PRMT5 dimethylation H4R3 symmetrical in proximal promoter AR. Furthermore, knockdown of PRMT5 abolished binding pICln (but not vice versa) to the proximal promoter region AR, showed that recruiting PRMT5 plan to AR AR promoter to activate transcription. Analysis of differential gene expression in cells 22Rv1 PRMT5 and pICln confirms that both regulate androgen signaling pathways.
Additionally, PRMT5 and pICln protein expression was positively correlated with AR and AR-V7 protein expression in CRPC tissues and their expression is highly correlated to the level of mRNA in several publicly available datasets CRPC. Our results show that targeting PRMT5 or pICln can be explored as a new therapy for the treatment of CRPC by suppressing the expression of AR and AR AR splice variants to avoid reactivation.
Chimerism as a basis for improvement of organ
Organ and tissue repair is a complex process that involves signaling molecules, growth factors and cell cycle regulators acting in concert to promote cell division and differentiation at the site of injury. In embryonic development, the fetal progenitor cells are actively involved in reparations and displays biphasic interaction with the mother; and there is a constant trade fetal cells into the maternal circulation and vice versa.
This phenomenon of fetal microchimerism may have a significant impact given the primitive multilineage properties of these cells. In published work, we have reported that fetal-derived placental cells express the homeodomain protein CDX2 retain all the “stem” of embryonic stem cell functional protein is not blessed with additional functionality in the areas of growth, survival, homing, and immune modulation.
DTT (Molecular Biology Grade) |
|||
| CE133 | GeneOn | 25 g | EUR 243.6 |
NAD (Molecular Biology Grade) |
|||
| CE196 | GeneOn | 1 g | EUR 72 |
NAD (Molecular Biology Grade) |
|||
| CE197 | GeneOn | 5 g | EUR 165.6 |
NBT (Molecular Biology Grade) |
|||
| CE209 | GeneOn | 1 g | EUR 123.6 |
NBT (Molecular Biology Grade) |
|||
| CE210 | GeneOn | 5 g | EUR 360 |
DMSO, Molecular Biology Grade |
|||
| 40470006-1 | Glycomatrix | 100 mL | EUR 88.18 |
DMSO, Molecular Biology Grade |
|||
| 40470006-2 | Glycomatrix | 250 mL | EUR 150.19 |
DMSO, Molecular Biology Grade |
|||
| 40470006-3 | Glycomatrix | 500 mL | EUR 279.26 |
EGTA, Molecular Biology Grade |
|||
| 40500028-2 | Glycomatrix | 50 g | EUR 106.43 |
EGTA, Molecular Biology Grade |
|||
| 40500028-3 | Glycomatrix | 100 g | EUR 177.58 |
EGTA, Molecular Biology Grade |
|||
| 40500028-4 | Glycomatrix | 500 g | EUR 603.19 |
EGTA, Molecular Biology Grade |
|||
| 40500028-5 | Glycomatrix | 1 kg | EUR 912.98 |
EGTA, Molecular Biology Grade |
|||
| 40500028-6 | Glycomatrix | 2 kg | EUR 1687.94 |
BCIP (Molecular Biology Grade) |
|||
| CE108 | GeneOn | 250 mg | EUR 75.6 |
BCIP (Molecular Biology Grade) |
|||
| CE109 | GeneOn | 1 g | EUR 108 |
DAPI (Molecular Biology Grade) |
|||
| CE117 | GeneOn | 5 mg | EUR 72 |
DAPI (Molecular Biology Grade) |
|||
| CE118 | GeneOn | 25 mg | EUR 159.6 |
DAPI (Molecular Biology Grade) |
|||
| CE119 | GeneOn | 100 mg | EUR 382.8 |
Tris (Molecular Biology Grade) |
|||
| CE237 | GeneOn | 500 g | EUR 106.8 |
Tris (Molecular Biology Grade) |
|||
| CE238 | GeneOn | 1 kg | EUR 153.6 |
Tris (Molecular Biology Grade) |
|||
| CE239 | GeneOn | 5 kg | EUR 535.2 |
Casein, for Molecular Biology |
|||
| MB279-100G | EWC Diagnostics | 1 unit | EUR 110.77 |
|
Description: Casein, for Molecular Biology |
|||
Casein, for Molecular Biology |
|||
| MB279-500G | EWC Diagnostics | 1 unit | EUR 387.65 |
|
Description: Casein, for Molecular Biology |
|||
CHAPS (Molecular Biology Grade) |
|||
| CE114 | GeneOn | 1 g | EUR 66 |
CHAPS (Molecular Biology Grade) |
|||
| CE115 | GeneOn | 5 g | EUR 157.2 |
CHAPS (Molecular Biology Grade) |
|||
| CE116 | GeneOn | 25 g | EUR 492 |
HEPES (Molecular Biology Grade) |
|||
| CE171 | GeneOn | 100 g | EUR 98.4 |
HEPES (Molecular Biology Grade) |
|||
| CE172 | GeneOn | 500 g | EUR 268.8 |
HEPES (Molecular Biology Grade) |
|||
| CE173 | GeneOn | 1 kg | EUR 424.8 |
Water (Molecular Biology Grade) |
|||
| CE243 | GeneOn | 500 ml | EUR 62.4 |
Water (Molecular Biology Grade) |
|||
| CE244 | GeneOn | 1 l | EUR 67.2 |
Molecular Biology Grade Water |
|||
| ML024-100ML | EWC Diagnostics | 1 unit | EUR 3.54 |
|
Description: Molecular Biology Grade Water |
|||
Molecular Biology Grade Water |
|||
| ML024-10X100ML | EWC Diagnostics | 1 unit | EUR 29.52 |
|
Description: Molecular Biology Grade Water |
|||
Molecular Biology Grade Water |
|||
| ML024-10X500ML | EWC Diagnostics | 1 unit | EUR 87.91 |
|
Description: Molecular Biology Grade Water |
|||
Molecular Biology Grade Water |
|||
| ML024-500ML | EWC Diagnostics | 1 unit | EUR 12.56 |
|
Description: Molecular Biology Grade Water |
|||
Molecular Biology Grade Water |
|||
| ML064-100ML | EWC Diagnostics | 1 unit | EUR 3.67 |
|
Description: Molecular Biology Grade Water |
|||
Molecular Biology Grade Water |
|||
| ML064-10X100ML | EWC Diagnostics | 1 unit | EUR 25.38 |
|
Description: Molecular Biology Grade Water |
|||
Molecular Biology Grade Water |
|||
| ML064-500ML | EWC Diagnostics | 1 unit | EUR 10.81 |
|
Description: Molecular Biology Grade Water |
|||
Sucrose for molecular biology |
|||
| 27580 | Sisco Laboratories | 500 Gms | EUR 4.11 |
|
Description: Part A |
|||
Agarose, Molecular Biology Grade |
|||
| 40100164-1 | Bio-WORLD | 25 g | Ask for price |
Agarose, Molecular Biology Grade |
|||
| 40100164-2 | Bio-WORLD | 50 g | Ask for price |
Agarose, Molecular Biology Grade |
|||
| 40100164-3 | Bio-WORLD | 100 g | Ask for price |
Agarose, Molecular Biology Grade |
|||
| 40100164-4 | Bio-WORLD | 500 g | Ask for price |
Agarose, Molecular Biology Grade |
|||
| 40100164-5 | Bio-WORLD | 1 kg | Ask for price |
Glycine (Molecular Biology Grade) |
|||
| CE158 | GeneOn | 1 kg | EUR 84 |
Glycine (Molecular Biology Grade) |
|||
| CE159 | GeneOn | 5 kg | EUR 228 |
Tween20 (Molecular Biology Grade) |
|||
| CE242 | GeneOn | 1 l | EUR 106.8 |
Agarose (Molecular Biology Grade) |
|||
| abx299715-100g | Abbexa | 100 µg | Ask for price |
Agarose (Molecular Biology Grade) |
|||
| abx299715-20g | Abbexa | 20 µg | EUR 525 |
Agarose (Molecular Biology Grade) |
|||
| abx299715-50g | Abbexa | 50 µg | Ask for price |
Lysozyme (Molecular Biology Grade) |
|||
| CE188 | GeneOn | 1 g | EUR 70.8 |
Lysozyme (Molecular Biology Grade) |
|||
| CE189 | GeneOn | 10 g | EUR 247.2 |
Lysozyme (Molecular Biology Grade) |
|||
| CE189L | GeneOn | 50 g | EUR 310 |
Lysozyme (Molecular Biology Grade) |
|||
| CE189XL | GeneOn | 250 g | EUR 1050 |
Urea for molecular biology, 99.5% |
|||
| 21113 | Sisco Laboratories | 500 Gms | EUR 6.5 |
|
Description: Part A |
|||
DEAE Cellulose 52 analytical grade for molecular biology |
|||
| 10529 | Sisco Laboratories | 5 Gms | EUR 16.28 |
|
Description: Part B |
|||
DEAE Cellulose 11 analytical grade for molecular biology |
|||
| 47478 | Sisco Laboratories | 5 Gms | EUR 18.38 |
|
Description: Part B |
|||
DEAE Cellulose 23 analytical grade for molecular biology |
|||
| 57136 | Sisco Laboratories | 5 Gms | EUR 20.7 |
|
Description: Part B |
|||
DEAE Cellulose 32 analytical grade for molecular biology |
|||
| 92321 | Sisco Laboratories | 5 Gms | EUR 25.73 |
|
Description: Part B |
|||
"10X PBS, Molecular Biology Grade" |
|||
| ML023-100ML | EWC Diagnostics | 1 unit | EUR 17.65 |
|
Description: "10X PBS, Molecular Biology Grade" |
|||
10X PBS, Molecular Biology Grade |
|||
| ML023-500ML | EWC Diagnostics | 1 unit | EUR 38.97 |
|
Description: 10X PBS, Molecular Biology Grade |
|||
"10X TBS, Molecular Biology Grade" |
|||
| ML029-100ML | EWC Diagnostics | 1 unit | EUR 19.04 |
|
Description: "10X TBS, Molecular Biology Grade" |
|||
"10X TBS, Molecular Biology Grade" |
|||
| ML029-500ML | EWC Diagnostics | 1 unit | EUR 40.48 |
|
Description: "10X TBS, Molecular Biology Grade" |
|||
10X TBS, Molecular Biology Grade |
|||
| ML029-6X500ML | EWC Diagnostics | 1 unit | EUR 138.56 |
|
Description: 10X TBS, Molecular Biology Grade |
|||
Xylene for molecular biology, 99.5% |
|||
| 45122 | Sisco Laboratories | 250 ml | EUR 2.81 |
|
Description: Part A |
|||
Tween 20, Molecular Biology Grade |
|||
| T9100-010 | GenDepot | 100ml | EUR 86.4 |
Tween 20, Molecular Biology Grade |
|||
| T9100-050 | GenDepot | 500ml | EUR 133.2 |
Tween 20, Molecular Biology Grade |
|||
| T9100-100 | GenDepot | 1L | EUR 160.8 |
Acetone for molecular biology, 99.8% |
|||
| 27498 | Sisco Laboratories | 500 ml | EUR 3.76 |
|
Description: Part A |
|||
Glycine for molecular biology, 99.5% |
|||
| 64072 | Sisco Laboratories | 100 Gms | EUR 1.64 |
|
Description: Part A |
|||
Protamine Sulfate for molecular biology, 90-110% |
|||
| 78349 | Sisco Laboratories | 1 Gms | EUR 22.5 |
|
Description: Part B |
|||
100mL Molecular Biology Grade - PK6 |
|||
| 46-000-CI | Scientific Laboratory Supplies | PK6 | EUR 83.7 |
500mL Molecular Biology Grade - PK6 |
|||
| 46-000-CV | Scientific Laboratory Supplies | PK6 | EUR 155.25 |
Carbinol for molecular biology, 99.5% |
|||
| 34883 | Sisco Laboratories | 500 ml | EUR 6.23 |
|
Description: Part A |
|||
Methanol for molecular biology, 99.5% |
|||
| 96446 | Sisco Laboratories | 500 ml | EUR 6.23 |
|
Description: Part A |
|||
Boric Acid, Molecular Biology Grade |
|||
| 40200060-1 | Glycomatrix | 500 g | EUR 46.16 |
Boric Acid, Molecular Biology Grade |
|||
| 40200060-2 | Glycomatrix | 1 kg | EUR 76.66 |
Boric Acid, Molecular Biology Grade |
|||
| 40200060-3 | Glycomatrix | 2.5 kg | EUR 145.5 |
D(+)-Sucrose (Molecular Biology Grade) |
|||
| CE224 | GeneOn | 500 g | EUR 67.2 |
D(+)-Sucrose (Molecular Biology Grade) |
|||
| CE225 | GeneOn | 1 kg | EUR 84 |
D(+)-Sucrose (Molecular Biology Grade) |
|||
| CE226 | GeneOn | 5 kg | EUR 207.6 |
Formamide for molecular biology, 99.5% |
|||
| 30349 | Sisco Laboratories | 500 ml | EUR 5.82 |
|
Description: Part A |
|||
Imidazole for molecular biology, 99.5% |
|||
| 61510 | Sisco Laboratories | 25 Gms | EUR 5.47 |
|
Description: Part A |
|||
20xSSC, Molecular Biology Grade, pH7.0 |
|||
| TBS5033-1L | Tribioscience | 1L | EUR 67 |
Glycerol 87 % (Molecular Biology Grade) |
|||
| CE154 | GeneOn | 1 l | EUR 93.6 |
MOPS buffer (Molecular Biology Grade) |
|||
| CE194 | GeneOn | 100 g | EUR 102 |
MOPS buffer (Molecular Biology Grade) |
|||
| CE195 | GeneOn | 250 g | EUR 169.2 |
Chloroform for molecular biology, 99.8% |
|||
| 96764 | Sisco Laboratories | 100 ml | EUR 3.08 |
|
Description: Part A |
|||
AccuGENE Molecular Biology Water 1L |
|||
| LO51200 | Westburg | each | EUR 127.13 |
Urea, suitable for molecular biology |
|||
| GE1210 | Glentham Life Sciences | 500g | EUR 53.1 |
Urea, suitable for molecular biology |
|||
| GE1210-1 | Glentham Life Sciences | 1 | EUR 58 |
Urea, suitable for molecular biology |
|||
| GE1210-1KG | Glentham Life Sciences | 1 kg | EUR 106.8 |
Urea, suitable for molecular biology |
|||
| GE1210-500 | Glentham Life Sciences | 500 | EUR 33.1 |
Urea, suitable for molecular biology |
|||
| GE1210-500G | Glentham Life Sciences | 500 g | EUR 76.8 |
Agarose, Molecular Biology Grade, 100g |
|||
| PC0701-100g | Vivantis | each | Ask for price |
Agarose, Molecular Biology Grade, 1kg |
|||
| PC0701-1kg | Vivantis | each | Ask for price |
Agarose, Molecular Biology Grade, 500g |
|||
| PC0701-500g | Vivantis | each | Ask for price |
Dimethylsulfoxide (Molecular Biology Grade) |
|||
| CE120 | GeneOn | 100 ml | EUR 66 |
Dimethylsulfoxide (Molecular Biology Grade) |
|||
| CE121 | GeneOn | 500 ml | EUR 110.4 |
AccuGENE Molecular Biology Water 10L |
|||
| LO51223 | Westburg | each | EUR 462.67 |
AccuGENE Molecular Biology Water 20L |
|||
| LO51224 | Westburg | each | EUR 786.53 |
TritonX-100 (Molecular Biology Grade) |
|||
| CE240 | GeneOn | 500 ml | EUR 67.2 |
TritonX-100 (Molecular Biology Grade) |
|||
| CE241 | GeneOn | 1 l | EUR 79.2 |
Ficoll 400® for molecular biology |
|||
| 45460 | Sisco Laboratories | 5 Gms | EUR 15.6 |
|
Description: Part B |
|||
Triethylamine for molecular biology, 99.5% |
|||
| 55221 | Sisco Laboratories | 500 ml | EUR 4.11 |
|
Description: Part A |
|||
Cesium Chloride, Molecular Biology Grade |
|||
| 40300060-1 | Glycomatrix | 50 g | EUR 45.77 |
Water, Ultrapure Molecular Biology Grade |
|||
| 41024-4L | Biotium | 4L | EUR 79 |
|
Description: N/A |
|||
Water, Ultrapure Molecular Biology Grade |
|||
| 41024-4L-1 | Biotium | EA | EUR 79 |
Bis-Acrylamid (Molecular Biology Grade) |
|||
| CE110 | GeneOn | 50 g | EUR 94.8 |
Bis-Acrylamid (Molecular Biology Grade) |
|||
| CE111 | GeneOn | 250 g | EUR 259.2 |
Sodium chloride (Molecular Biology Grade) |
|||
| CE205 | GeneOn | 500 g | EUR 62.4 |
Sodium chloride (Molecular Biology Grade) |
|||
| CE206 | GeneOn | 1 kg | EUR 70.8 |
Sodium chloride (Molecular Biology Grade) |
|||
| CE207 | GeneOn | 5 kg | EUR 123.6 |
Agarose UltraPhor for molecular biology |
|||
| 27813 | Sisco Laboratories | 10 Gms | EUR 46.5 |
|
Description: Part B |
|||
Agarose Tablets (Molecular Biology Grade) |
|||
| MBS402002-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Boric Acid for molecular biology, 99.5% |
|||
| 22311 | Sisco Laboratories | 250 Gms | EUR 4.04 |
|
Description: Part A |
|||
Lithium Chloride, Molecular Biology Grade |
|||
| 41200036-1 | Glycomatrix | 100 g | EUR 41.7 |
Lithium Chloride, Molecular Biology Grade |
|||
| 41200036-2 | Glycomatrix | 500 g | EUR 108.38 |
Ammonium sulfate (Molecular Biology Grade) |
|||
| CE105 | GeneOn | 250 g | EUR 55.2 |
Ammonium sulfate (Molecular Biology Grade) |
|||
| CE106 | GeneOn | 1 kg | EUR 72 |
Ammonium sulfate (Molecular Biology Grade) |
|||
| CE107 | GeneOn | 5 kg | EUR 153.6 |
Urea Crystalline (Molecular Biology Grade) |
|||
| CE167 | GeneOn | 1 kg | EUR 72 |
Urea Crystalline (Molecular Biology Grade) |
|||
| CE168 | GeneOn | 5 kg | EUR 181.2 |
1L Molecular Biology Grade Water - PK6 |
|||
| 46-000-CM | Scientific Laboratory Supplies | PK6 | EUR 221.4 |
ACES Buffer for molecular biology, 99.5% |
|||
| 27907 | Sisco Laboratories | 5 Gms | EUR 5.4 |
|
Description: Part B |
|||
Triton X-100 for molecular biology |
|||
| 64518 | Sisco Laboratories | 100 ml | EUR 6.02 |
|
Description: Part A |
|||
MOPS Buffer for molecular biology, 99% |
|||
| 66043 | Sisco Laboratories | 25 Gms | EUR 10.28 |
|
Description: Part B |
|||
Vitamin B12 for molecular biology, 97% |
|||
| 77472 | Sisco Laboratories | 250 Mg | EUR 5.78 |
|
Description: Part B |
|||
2-Mercaptoethanol ?For Molecular Biology |
|||
| MB041-100ML | EWC Diagnostics | 1 unit | EUR 9.02 |
|
Description: 2-Mercaptoethanol ?For Molecular Biology |
|||
2-Mercaptoethanol ?For Molecular Biology |
|||
| MB041-500ML | EWC Diagnostics | 1 unit | EUR 26.47 |
|
Description: 2-Mercaptoethanol ?For Molecular Biology |
|||
Tweezers, 3 Dumont INOX, biology grade |
|||
| 21972-1 | Polysciences Europe GmbH | 1each | EUR 56 |
Tweezers, 3 Dumont INOX, biology grade |
|||
| 21972-12 | Polysciences Europe GmbH | 12each | EUR 502 |
Tweezers, 3C Dumont INOX, biology grade |
|||
| 21973-1 | Polysciences Europe GmbH | 1each | EUR 74 |
Tweezers, 3C Dumont INOX, biology grade |
|||
| 21973-12 | Polysciences Europe GmbH | 12each | EUR 644 |
Tweezers, 5 Dumont INOX, biology grade |
|||
| 21974-1 | Polysciences Europe GmbH | 1each | EUR 55 |
Tweezers, 5 Dumont INOX, biology grade |
|||
| 21974-12 | Polysciences Europe GmbH | 12each | EUR 601 |
Tweezers, 7 Dumont INOX, biology grade |
|||
| 21975-1 | Polysciences Europe GmbH | 1each | EUR 83 |
Tweezers, 7 Dumont INOX, biology grade |
|||
| 21975-12 | Polysciences Europe GmbH | 12each | EUR 789 |
HEPES Buffer for molecular biology, 99.5% |
|||
| 16826 | Sisco Laboratories | 25 Gms | EUR 6.3 |
|
Description: Part B |
|||
Sodium Azide for molecular biology, 99% |
|||
| 17782 | Sisco Laboratories | 100 Gms | EUR 5.47 |
|
Description: Part A |
|||
CHAPS Buffer for molecular biology, 99.5% |
|||
| 21420 | Sisco Laboratories | 1 Gms | EUR 10.73 |
|
Description: Part B |
|||
Agarose Low EEO for molecular biology |
|||
| 36601 | Sisco Laboratories | 10 Gms | EUR 5.1 |
|
Description: Part B |
|||
PIPES Buffer for molecular biology, 99% |
|||
| 49159 | Sisco Laboratories | 100 Gms | EUR 26.03 |
|
Description: Part B |
|||
10X MOPS Buffer for molecular biology |
|||
| 68078 | Sisco Laboratories | 100 ml | EUR 4.5 |
|
Description: Part B |
|||
Glycerol waterfree (Molecular Biology Grade) |
|||
| CE155 | GeneOn | 500 ml | EUR 78 |
Glycerol waterfree (Molecular Biology Grade) |
|||
| CE156 | GeneOn | 1 l | EUR 102 |
Glycerol waterfree (Molecular Biology Grade) |
|||
| CE157 | GeneOn | 2.5 l | EUR 170.4 |
Tris - Hydrochloride (Molecular Biology Grade) |
|||
| CE234 | GeneOn | 250 g | EUR 99.6 |
Tris - Hydrochloride (Molecular Biology Grade) |
|||
| CE235 | GeneOn | 500 g | EUR 144 |
Tris - Hydrochloride (Molecular Biology Grade) |
|||
| CE236 | GeneOn | 1 kg | EUR 223.2 |
SSC Buffer (20X) (Molecular Biology Grade) |
|||
| CE229 | GeneOn | 1 l | EUR 86.4 |
Agarose High EEO for molecular biology |
|||
| 60645 | Sisco Laboratories | 25 Gms | EUR 13.8 |
|
Description: Part B |
|||
Jasmonic Acid for molecular biology, 95% |
|||
| 79238 | Sisco Laboratories | 25 Mg | EUR 120.9 |
|
Description: Part B |
|||
Oil Red O for molecular biology, 75% |
|||
| 23576 | Sisco Laboratories | 25 Gms | EUR 5.33 |
|
Description: Part B |
|||
These cells showed multipotency in vitro and in vivo, causing spontaneous beating cardiomyocytes and blood vessel cells. In the mouse model, cells from the placenta of women CDX2 can be administered intravenously to male rats myocardial infarction with subsequent homing of cells to the area of infarction CDX2 and evidence of cell regeneration with improved cardiac function.