The Notch signaling network to determine stemness in various tissues and targeting indicates activity on malignant brain cancer by gamma-Secretase inhibitor (GSI) has shown promising preclinical success. However, the translation of the remains clinically challenging because the side effects of severe toxicity and the emergence of resistance to therapy. Better anti-Notch therapies directed, particularly directed against the tumor promoting receptor Notch 1 signaling framework, and biomarkers that predict response to therapy of the highest clinical needs.
We assessed several patient dataset to investigate the clinical relevance of activation of Notch1 and possible differential distribution between molecular subtypes in brain cancer. We functionally assess the biological effects of the first-in-man is tested blocking antibody against the receptor Notch1 (brontictuzumab, BRON) in the collection of stem-like cell model of glioma (GSC) and compared the effect of genetic inhibition of Notch1 and pharmacological classic Notch inhibitor treatment using gamma-Secretase MRK003 inhibitor.
We also assess the effect on winged (NTB) stem cell activation signal, which includes interrogation NTB models genetic inhibition. calculated transcription Notch pathway activation score we upregulated in neural stem cells, as compared to astrocytes; as well as in GSCs, compared with differentiated glioblastoma cells.
In addition, the signature Notch is a glioblastoma clinical prediction on the discovery and validation of our patient cohort. Notch signature significantly elevated in tumors with mutant genomes IDH1 and tumors without 1p and 19q co-deletion. In GSCs with increased expression of Notch1, BRON treatment block gene transcription Notch pathway target Hes1 / Hey1, significantly reducing the amount of cleaved Notch1 receptor protein and cause a significant decrease in cellular invasion. Benchmarking this phenotype to that observed with the genetic inhibition of Notch1 in the appropriate cell model did result in a higher reduction of cell invasion under chemotherapy.
BRON treatment of the signs resulting from upregulation of winged (NTB) stem cell activity signals, and vice versa, due to blockage of WNT signaling induced expression of Notch target genes in our model. We extend the list of evidence that elevated expression of Notch signaling biomarker signature stating the prevalence of stem cells and clinically useful for predicting negative in glioblastoma. By using functional tests, we first validated in human Notch1 receptor-specific antibodies were tested as promising candidates in the context of neuro-oncology and biomarker panel proposes to predict the durability and therapeutic success of these treatment options. We note that the observed phenotype appears to be partial because of Notch1 blockage and lead candidate to target signal activation off.
Further studies addressing the possible emergence of resistance to therapy because NTB need activation will be done. We further validated our 3D disease modeling technology to be a benefit for development projects.
Protein arginine methyltransferase 5 pICln promote androgen receptor-dependent transcription in castration-resistant prostate cancer
The majority of prostate cancer therapy aims to inhibit the androgen receptor (AR) signaling. However, AR reactivation certainly encourage the development of disease castration-resistant prostate cancer (CRPC). Here we show that the protein arginine methyltransferase 5 (PRMT5) serves as an epigenetic activator of transcription AR in CRPC, requires cooperation with methylosome pICln subunit. In vitro and in xenograft tumors in mice, targeting PRMT5 or pICln pressed CRPC cell growth.
Full-length AR and AR-V7 good transcriptional activation required PRMT5 and pICln but not MEP50. This activation of transcription-mediated accompanied by PRMT5 dimethylation H4R3 symmetrical in proximal promoter AR. Furthermore, knockdown of PRMT5 abolished binding pICln (but not vice versa) to the proximal promoter region AR, showed that recruiting PRMT5 plan to AR AR promoter to activate transcription. Analysis of differential gene expression in cells 22Rv1 PRMT5 and pICln confirms that both regulate androgen signaling pathways.
Additionally, PRMT5 and pICln protein expression was positively correlated with AR and AR-V7 protein expression in CRPC tissues and their expression is highly correlated to the level of mRNA in several publicly available datasets CRPC. Our results show that targeting PRMT5 or pICln can be explored as a new therapy for the treatment of CRPC by suppressing the expression of AR and AR AR splice variants to avoid reactivation.
Chimerism as a basis for improvement of organ
Organ and tissue repair is a complex process that involves signaling molecules, growth factors and cell cycle regulators acting in concert to promote cell division and differentiation at the site of injury. In embryonic development, the fetal progenitor cells are actively involved in reparations and displays biphasic interaction with the mother; and there is a constant trade fetal cells into the maternal circulation and vice versa.
This phenomenon of fetal microchimerism may have a significant impact given the primitive multilineage properties of these cells. In published work, we have reported that fetal-derived placental cells express the homeodomain protein CDX2 retain all the “stem” of embryonic stem cell functional protein is not blessed with additional functionality in the areas of growth, survival, homing, and immune modulation.
DTT (Molecular Biology Grade) |
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| CE133 | GeneOn | 25 g | EUR 170 |
NAD (Molecular Biology Grade) |
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| CE196 | GeneOn | 1 g | EUR 34 |
NAD (Molecular Biology Grade) |
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| CE197 | GeneOn | 5 g | EUR 137 |
NBT (Molecular Biology Grade) |
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| CE209 | GeneOn | 1 g | EUR 96 |
NBT (Molecular Biology Grade) |
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| CE210 | GeneOn | 5 g | EUR 345 |
BCIP (Molecular Biology Grade) |
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| CE108 | GeneOn | 250 mg | Ask for price |
BCIP (Molecular Biology Grade) |
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| CE109 | GeneOn | 1 g | EUR 82 |
DAPI (Molecular Biology Grade) |
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| CE117 | GeneOn | 5 mg | EUR 40 |
DAPI (Molecular Biology Grade) |
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| CE118 | GeneOn | 25 mg | EUR 133 |
DAPI (Molecular Biology Grade) |
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| CE119 | GeneOn | 100 mg | EUR 281 |
Tris (Molecular Biology Grade) |
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| CE237 | GeneOn | 500 g | EUR 79 |
Tris (Molecular Biology Grade) |
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| CE238 | GeneOn | 1 kg | EUR 135 |
Tris (Molecular Biology Grade) |
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| CE239 | GeneOn | 5 kg | EUR 608 |
Casein, for Molecular Biology |
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| MB279-100G | EWC Diagnostics | 1 unit | EUR 110.77 |
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Description: Casein, for Molecular Biology |
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Casein, for Molecular Biology |
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| MB279-500G | EWC Diagnostics | 1 unit | EUR 387.65 |
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Description: Casein, for Molecular Biology |
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Sucrose for molecular biology |
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| 27580 | Sisco Laboratories | 500 Gms | EUR 4.11 |
|
Description: Part A |
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CHAPS (Molecular Biology Grade) |
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| CE114 | GeneOn | 1 g | Ask for price |
CHAPS (Molecular Biology Grade) |
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| CE115 | GeneOn | 5 g | EUR 97 |
CHAPS (Molecular Biology Grade) |
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| CE116 | GeneOn | 25 g | EUR 319 |
HEPES (Molecular Biology Grade) |
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| CE171 | GeneOn | 100 g | EUR 40 |
HEPES (Molecular Biology Grade) |
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| CE172 | GeneOn | 500 g | EUR 162 |
HEPES (Molecular Biology Grade) |
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| CE173 | GeneOn | 1 kg | EUR 285 |
Water (Molecular Biology Grade) |
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| CE243 | GeneOn | 500 ml | EUR 62.4 |
Water (Molecular Biology Grade) |
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| CE244 | GeneOn | 1 l | EUR 35 |
Molecular Biology Grade Water |
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| ML024-100ML | EWC Diagnostics | 1 unit | EUR 3.54 |
|
Description: Molecular Biology Grade Water |
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Molecular Biology Grade Water |
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| ML024-10X100ML | EWC Diagnostics | 1 unit | EUR 29.52 |
|
Description: Molecular Biology Grade Water |
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Molecular Biology Grade Water |
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| ML024-10X500ML | EWC Diagnostics | 1 unit | EUR 87.91 |
|
Description: Molecular Biology Grade Water |
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Molecular Biology Grade Water |
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| ML024-500ML | EWC Diagnostics | 1 unit | EUR 12.56 |
|
Description: Molecular Biology Grade Water |
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Molecular Biology Grade Water |
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| ML064-100ML | EWC Diagnostics | 1 unit | EUR 3.67 |
|
Description: Molecular Biology Grade Water |
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Molecular Biology Grade Water |
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| ML064-10X100ML | EWC Diagnostics | 1 unit | EUR 25.38 |
|
Description: Molecular Biology Grade Water |
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Molecular Biology Grade Water |
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| ML064-500ML | EWC Diagnostics | 1 unit | EUR 10.81 |
|
Description: Molecular Biology Grade Water |
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Glycin (Molecular Biology Grade) |
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| CE158 | GeneOn | 1 kg | EUR 61 |
Glycin (Molecular Biology Grade) |
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| CE159 | GeneOn | 5 kg | EUR 221 |
Agarose, Molecular Biology Grade |
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| 40100164-1 | Bio-WORLD | 25 g | Ask for price |
Agarose, Molecular Biology Grade |
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| 40100164-2 | Bio-WORLD | 50 g | Ask for price |
Agarose, Molecular Biology Grade |
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| 40100164-3 | Bio-WORLD | 100 g | Ask for price |
Agarose, Molecular Biology Grade |
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| 40100164-4 | Bio-WORLD | 500 g | Ask for price |
Agarose, Molecular Biology Grade |
|||
| 40100164-5 | Bio-WORLD | 1 kg | Ask for price |
Agarose (Molecular Biology Grade) |
|||
| abx299715-100g | Abbexa | 100 µg | Ask for price |
Agarose (Molecular Biology Grade) |
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| abx299715-20g | Abbexa | 20 µg | EUR 525 |
Agarose (Molecular Biology Grade) |
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| abx299715-50g | Abbexa | 50 µg | Ask for price |
Lysozyme (Molecular Biology Grade) |
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| CE188 | GeneOn | 1 g | EUR 70.8 |
Lysozyme (Molecular Biology Grade) |
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| CE189 | GeneOn | 10 g | EUR 80 |
Lysozyme (Molecular Biology Grade) |
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| CE189L | GeneOn | 50 g | EUR 310 |
Lysozyme (Molecular Biology Grade) |
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| CE189XL | GeneOn | 250 g | EUR 1050 |
Urea for molecular biology, 99.5% |
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| 21113 | Sisco Laboratories | 500 Gms | EUR 6.5 |
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Description: Part A |
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Xylene for molecular biology, 99.5% |
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| 45122 | Sisco Laboratories | 250 ml | EUR 2.81 |
|
Description: Part A |
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20X SSC - Molecular Biology Grade |
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| IBS-BS011 | iNtRON Biotechnology Inc | 1L | EUR 24.5 |
20X SSP - Molecular Biology Grade |
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| IBS-BS012 | iNtRON Biotechnology Inc | 1L | EUR 31.5 |
"10X PBS, Molecular Biology Grade" |
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| ML023-100ML | EWC Diagnostics | 1 unit | EUR 17.65 |
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Description: "10X PBS, Molecular Biology Grade" |
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10X PBS, Molecular Biology Grade |
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| ML023-500ML | EWC Diagnostics | 1 unit | EUR 38.97 |
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Description: 10X PBS, Molecular Biology Grade |
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"10X TBS, Molecular Biology Grade" |
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| ML029-100ML | EWC Diagnostics | 1 unit | EUR 19.04 |
|
Description: "10X TBS, Molecular Biology Grade" |
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"10X TBS, Molecular Biology Grade" |
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| ML029-500ML | EWC Diagnostics | 1 unit | EUR 40.48 |
|
Description: "10X TBS, Molecular Biology Grade" |
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10X TBS, Molecular Biology Grade |
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| ML029-6X500ML | EWC Diagnostics | 1 unit | EUR 138.56 |
|
Description: 10X TBS, Molecular Biology Grade |
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Acetone for molecular biology, 99.8% |
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| 27498 | Sisco Laboratories | 500 ml | EUR 3.76 |
|
Description: Part A |
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Glycine for molecular biology, 99.5% |
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| 64072 | Sisco Laboratories | 100 Gms | EUR 1.64 |
|
Description: Part A |
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20X SSPE - Molecular Biology Grade |
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| IBS-BS013 | iNtRON Biotechnology Inc | 1L | EUR 31.5 |
20X SSPE - Molecular Biology Grade |
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| IBS-BS013a | iNtRON Biotechnology Inc | 500 mL | EUR 21 |
Tween 20, Molecular Biology Grade |
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| T9100-010 | GenDepot | 100ml | EUR 20 |
Tween 20, Molecular Biology Grade |
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| T9100-050 | GenDepot | 500ml | EUR 44 |
Tween 20, Molecular Biology Grade |
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| T9100-100 | GenDepot | 1L | EUR 62 |
DEAE Cellulose 52 analytical grade for molecular biology |
|||
| 10529 | Sisco Laboratories | 5 Gms | EUR 16.28 |
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Description: Part B |
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DEAE Cellulose 23 analytical grade for molecular biology |
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| 57136 | Sisco Laboratories | 5 Gms | EUR 20.7 |
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Description: Part B |
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DEAE Cellulose 11 analytical grade for molecular biology |
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| 47478 | Sisco Laboratories | 5 Gms | EUR 18.38 |
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Description: Part B |
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DEAE Cellulose 32 analytical grade for molecular biology |
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| 92321 | Sisco Laboratories | 5 Gms | EUR 25.73 |
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Description: Part B |
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Protamine Sulfate for molecular biology, 90-110% |
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| 78349 | Sisco Laboratories | 1 Gms | EUR 22.5 |
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Description: Part B |
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Carbinol for molecular biology, 99.5% |
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| 34883 | Sisco Laboratories | 500 ml | EUR 6.23 |
|
Description: Part A |
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100mL Molecular Biology Grade - PK6 |
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| 46-000-CI | Scientific Laboratory Supplies | PK6 | EUR 83.7 |
500mL Molecular Biology Grade - PK6 |
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| 46-000-CV | Scientific Laboratory Supplies | PK6 | EUR 155.25 |
Methanol for molecular biology, 99.5% |
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| 96446 | Sisco Laboratories | 500 ml | EUR 6.23 |
|
Description: Part A |
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Formamide for molecular biology, 99.5% |
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| 30349 | Sisco Laboratories | 500 ml | EUR 5.82 |
|
Description: Part A |
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D(+)-Sucrose (Molecular Biology Grade) |
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| CE224 | GeneOn | 500 g | EUR 67.2 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE225 | GeneOn | 1 kg | EUR 42 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE226 | GeneOn | 5 kg | EUR 184 |
Imidazole for molecular biology, 99.5% |
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| 61510 | Sisco Laboratories | 25 Gms | EUR 5.47 |
|
Description: Part A |
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STM Buffer - Molecular Biology Grade |
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| IBS-BS016 | iNtRON Biotechnology Inc | 1L | EUR 56 |
20xSSC, Molecular Biology Grade, pH7.0 |
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| TBS5033-1L | Tribioscience | 1L | EUR 67 |
Glycerol 87 % (Molecular Biology Grade) |
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| CE154 | GeneOn | 1 l | EUR 61 |
MOPS buffer (Molecular Biology Grade) |
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| CE194 | GeneOn | 100 g | EUR 71 |
MOPS buffer (Molecular Biology Grade) |
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| CE195 | GeneOn | 250 g | EUR 142 |
Chloroform for molecular biology, 99.8% |
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| 96764 | Sisco Laboratories | 100 ml | EUR 3.08 |
|
Description: Part A |
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Urea, suitable for molecular biology |
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| GE1210 | Glentham Life Sciences | 500g | EUR 53.1 |
Urea, suitable for molecular biology |
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| GE1210-1 | Glentham Life Sciences | 1 | EUR 58 |
Urea, suitable for molecular biology |
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| GE1210-1KG | Glentham Life Sciences | 1 kg | EUR 106.8 |
Urea, suitable for molecular biology |
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| GE1210-500 | Glentham Life Sciences | 500 | EUR 33.1 |
Urea, suitable for molecular biology |
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| GE1210-500G | Glentham Life Sciences | 500 g | EUR 76.8 |
AccuGENE Molecular Biology Water 1L |
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| LO51200 | Westburg | each | EUR 127.13 |
Agarose, Molecular Biology Grade, 100g |
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| PC0701-100g | Vivantis | each | Ask for price |
Agarose, Molecular Biology Grade, 1kg |
|||
| PC0701-1kg | Vivantis | each | Ask for price |
Agarose, Molecular Biology Grade, 500g |
|||
| PC0701-500g | Vivantis | each | Ask for price |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE120 | GeneOn | 100 ml | EUR 66 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE121 | GeneOn | 500 ml | EUR 89 |
AccuGENE Molecular Biology Water 10L |
|||
| LO51223 | Westburg | each | EUR 462.67 |
AccuGENE Molecular Biology Water 20L |
|||
| LO51224 | Westburg | each | EUR 786.53 |
TritonX-100 (Molecular Biology Grade) |
|||
| CE240 | GeneOn | 500 ml | EUR 67.2 |
TritonX-100 (Molecular Biology Grade) |
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| CE241 | GeneOn | 1 l | EUR 79.2 |
STET Solution - Molecular Biology Grade |
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| IBS-BS014 | iNtRON Biotechnology Inc | 500 mL | EUR 35 |
Ficoll 400® for molecular biology |
|||
| 45460 | Sisco Laboratories | 5 Gms | EUR 15.6 |
|
Description: Part B |
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Triethylamine for molecular biology, 99.5% |
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| 55221 | Sisco Laboratories | 500 ml | EUR 4.11 |
|
Description: Part A |
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Boric Acid for molecular biology, 99.5% |
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| 22311 | Sisco Laboratories | 250 Gms | EUR 4.04 |
|
Description: Part A |
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Tween® 20 (Molecular Biology Grade) |
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| CE242 | GeneOn | 1 l | EUR 80 |
Agarose UltraPhor for molecular biology |
|||
| 27813 | Sisco Laboratories | 10 Gms | EUR 46.5 |
|
Description: Part B |
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Bis-Acrylamid (Molecular Biology Grade) |
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| CE110 | GeneOn | 50 g | EUR 73 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE111 | GeneOn | 250 g | EUR 266 |
Sodium chloride (Molecular Biology Grade) |
|||
| CE205 | GeneOn | 500 g | EUR 62.4 |
Sodium chloride (Molecular Biology Grade) |
|||
| CE206 | GeneOn | 1 kg | EUR 29 |
Sodium chloride (Molecular Biology Grade) |
|||
| CE207 | GeneOn | 5 kg | EUR 98 |
Water, Ultrapure Molecular Biology Grade |
|||
| 41024-4L | Biotium | 4L | EUR 79 |
|
Description: N/A |
|||
Water, Ultrapure Molecular Biology Grade |
|||
| 41024-4L-1 | Biotium | EA | EUR 79 |
Agarose Tablets (Molecular Biology Grade) |
|||
| MBS402002-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Ammonium sulfate (Molecular Biology Grade) |
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| CE105 | GeneOn | 250 g | EUR 55.2 |
Ammonium sulfate (Molecular Biology Grade) |
|||
| CE106 | GeneOn | 1 kg | EUR 39 |
Ammonium sulfate (Molecular Biology Grade) |
|||
| CE107 | GeneOn | 5 kg | EUR 142 |
Urea Crystalline (Molecular Biology Grade) |
|||
| CE167 | GeneOn | 1 kg | EUR 49 |
Urea Crystalline (Molecular Biology Grade) |
|||
| CE168 | GeneOn | 5 kg | EUR 197 |
ACES Buffer for molecular biology, 99.5% |
|||
| 27907 | Sisco Laboratories | 5 Gms | EUR 5.4 |
|
Description: Part B |
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Vitamin B12 for molecular biology, 97% |
|||
| 77472 | Sisco Laboratories | 250 Mg | EUR 5.78 |
|
Description: Part B |
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MOPS Buffer for molecular biology, 99% |
|||
| 66043 | Sisco Laboratories | 25 Gms | EUR 10.28 |
|
Description: Part B |
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Triton X-100 for molecular biology |
|||
| 64518 | Sisco Laboratories | 100 ml | EUR 6.02 |
|
Description: Part A |
|||
1L Molecular Biology Grade Water - PK6 |
|||
| 46-000-CM | Scientific Laboratory Supplies | PK6 | EUR 221.4 |
2-Mercaptoethanol ?For Molecular Biology |
|||
| MB041-100ML | EWC Diagnostics | 1 unit | EUR 9.02 |
|
Description: 2-Mercaptoethanol ?For Molecular Biology |
|||
2-Mercaptoethanol ?For Molecular Biology |
|||
| MB041-500ML | EWC Diagnostics | 1 unit | EUR 26.47 |
|
Description: 2-Mercaptoethanol ?For Molecular Biology |
|||
Sodium Azide for molecular biology, 99% |
|||
| 17782 | Sisco Laboratories | 100 Gms | EUR 5.47 |
|
Description: Part A |
|||
HEPES Buffer for molecular biology, 99.5% |
|||
| 16826 | Sisco Laboratories | 25 Gms | EUR 6.3 |
|
Description: Part B |
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Tweezers, 3 Dumont INOX, biology grade |
|||
| 21972-1 | Polysciences Europe GmbH | 1each | EUR 62.64 |
Tweezers, 3 Dumont INOX, biology grade |
|||
| 21972-12 | Polysciences Europe GmbH | 12each | EUR 559.44 |
Tweezers, 3C Dumont INOX, biology grade |
|||
| 21973-1 | Polysciences Europe GmbH | 1each | EUR 82.08 |
Tweezers, 3C Dumont INOX, biology grade |
|||
| 21973-12 | Polysciences Europe GmbH | 12each | EUR 717.12 |
Tweezers, 5 Dumont INOX, biology grade |
|||
| 21974-1 | Polysciences Europe GmbH | 1each | EUR 61.56 |
Tweezers, 5 Dumont INOX, biology grade |
|||
| 21974-12 | Polysciences Europe GmbH | 12each | EUR 669.6 |
Tweezers, 7 Dumont INOX, biology grade |
|||
| 21975-1 | Polysciences Europe GmbH | 1each | EUR 91.8 |
Tweezers, 7 Dumont INOX, biology grade |
|||
| 21975-12 | Polysciences Europe GmbH | 12each | EUR 878.04 |
Agarose Low EEO for molecular biology |
|||
| 36601 | Sisco Laboratories | 10 Gms | EUR 5.1 |
|
Description: Part B |
|||
CHAPS Buffer for molecular biology, 99.5% |
|||
| 21420 | Sisco Laboratories | 1 Gms | EUR 10.73 |
|
Description: Part B |
|||
10X MOPS Buffer for molecular biology |
|||
| 68078 | Sisco Laboratories | 100 ml | EUR 4.5 |
|
Description: Part B |
|||
PIPES Buffer for molecular biology, 99% |
|||
| 49159 | Sisco Laboratories | 100 Gms | EUR 26.03 |
|
Description: Part B |
|||
Glycerol waterfree (Molecular Biology Grade) |
|||
| CE155 | GeneOn | 500 ml | EUR 38 |
Glycerol waterfree (Molecular Biology Grade) |
|||
| CE156 | GeneOn | 1 l | EUR 66 |
Glycerol waterfree (Molecular Biology Grade) |
|||
| CE157 | GeneOn | 2.5 l | EUR 135 |
Tris - Hydrochloride (Molecular Biology Grade) |
|||
| CE234 | GeneOn | 250 g | EUR 71 |
Tris - Hydrochloride (Molecular Biology Grade) |
|||
| CE235 | GeneOn | 500 g | EUR 115 |
Tris - Hydrochloride (Molecular Biology Grade) |
|||
| CE236 | GeneOn | 1 kg | EUR 199 |
Jasmonic Acid for molecular biology, 95% |
|||
| 79238 | Sisco Laboratories | 25 Mg | EUR 120.9 |
|
Description: Part B |
|||
Agarose High EEO for molecular biology |
|||
| 60645 | Sisco Laboratories | 25 Gms | EUR 13.8 |
|
Description: Part B |
|||
SSC Buffer (20X) (Molecular Biology Grade) |
|||
| CE229 | GeneOn | 1 l | EUR 55 |
Oil Red O for molecular biology, 75% |
|||
| 23576 | Sisco Laboratories | 25 Gms | EUR 5.33 |
|
Description: Part B |
|||
Formamide deionized (Molecular Biology Grade) |
|||
| CE145 | GeneOn | 500 ml | EUR 61 |
Formamide deionized (Molecular Biology Grade) |
|||
| CE146 | GeneOn | 1 l | EUR 84 |
XTT sodium salt (Molecular Biology Grade) |
|||
| CE250 | GeneOn | 100 mg | EUR 180 |
XTT sodium salt (Molecular Biology Grade) |
|||
| CE251 | GeneOn | 500 mg | EUR 588 |
OORA00207-v1 - Deoxyribonuclease I (Bovine Pancreas) RNAse and Protease Free Molecular Biology Grade (500units) |
|||
| OORA00207-v1 | Aviva Systems Biology | 500units | EUR 305 |
Acriflavine Hydrochloride for molecular biology, 98.5%-105% |
|||
| 35188 | Sisco Laboratories | 5 Gms | EUR 4.05 |
|
Description: Part B |
|||
Sodium Chloride for molecular biology, 99.9% |
|||
| 33205 | Sisco Laboratories | 500 Gms | EUR 4.52 |
|
Description: Part A |
|||
Agarose Medium EEO for molecular biology |
|||
| 10423 | Sisco Laboratories | 10 Gms | EUR 6.75 |
|
Description: Part B |
|||
These cells showed multipotency in vitro and in vivo, causing spontaneous beating cardiomyocytes and blood vessel cells. In the mouse model, cells from the placenta of women CDX2 can be administered intravenously to male rats myocardial infarction with subsequent homing of cells to the area of infarction CDX2 and evidence of cell regeneration with improved cardiac function.