Devices

Highly-flexible label-free workstations for any kind of biomolecular interaction studies. Find the suitable device for your application.

bscreen

Label-free screening of over 10,000´s of samples with kinetics in one assay run.

/ Primary discovery screening
/ Higher throughput for secondary screening
/ Screen for primary target along with cross reactivity
/ enriched data sets enabled by kinetics

Screen more, faster with flexible assay design and receive richer data sets enabled by kinetics.

bscreen combines microarray technology with kinetics offering richer data sets that improve target identification and provide better lead candidates for characterization, acceleration the pipeline for new drug discoveries.

  • Screen more – Screen larger data sets without the limitations of working in microplates
  • Reduce Costs – Reduce the costs of screening by using less of your valuable sample
  • Improve Workflows – Develop new workflows utilizing the accelerator lab and in-house application support
  • Save Time – Speed up the process screening 10,000+ samples in 5 days total workflow from start to data
  • Enrich Data – Enrich data sets by providing insights through kinetic information
  • Better Targets – Provide better targets for characterization by catching low affinity binders and less false positives

 

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Technology
The bscreen combines the high-throughput of classic µ-array with the high-content of kinetic measurements. Up to 22,500 independent biomolecular interactions can be analysed simultaneously to gain information about binding affinities as well as association and dissociation rates (ka and kd).

Device
The bscreen is a µ-array workstation that allows you to observe the complete binding process on each spot of your µ-array in parallel. It automates flow through incubation, dissociation, data acquisition and regeneration. Integrated powerful fluidics allow for robust and reliable measurements.

Software
Measurement, sample handling and data acquisition is automatized within an easy to use software. In addition, the complementary data evaluation package offers a powerful tool for kinetic data analysis.

Consumables
The bscreen utilizes low-cost glass type sensor chips in the standard microscopic slide format. Format and surface technology are compatible usual printing equipment and methods. The Biametrics sensor chips come equipped with various coupling chemistries.

Samples
Interaction studies can be performed with almost any type of biomolecule, ranging from proteins, peptides, DNA/RNA up to viruses or (nano) particles. The system is compatible with standard buffers and media and even crude samples like serum or cell lysates.

bportable

The affordable benchtop device for label-free biomolecular interaction analysis.

/ Kinetic characterisation
/ Immunoassay development
/ Quality control and bioprocessing

An affordable way to access high-quality kinetic data.

bportable is a compact, small-footprint system for biomolecular interaction studies. By combining  kinetic data with affordability, bportable expands access to high-quality data. With a broad range of label-free measurements, like binding affinity and kinetic rate constants, you can make informed decisions quicker and move projects along faster.

Application fields for the b-portable include:

  • Protein/protein interactions
  • Kinetics
  • Calibration-free concentration analysis
  • Diagnostic research

 

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Technology

bportable features SCORE technology (single colour reflectometry) to observe interactions between biomolecules without using labels. This technology guarantees reproducible measurement signals and low baseline drift. With its precise optics and microfluidics, binding events are observed in a stable environment. Therefore, kinetic rate constants can be determined with high accuracy for a wide range of interactions.

Device

bportable offers an efficient and affordable solution to measure biomolecular interactions label-free and in real-time. With its small footprint, it is designed to perform kinetic measurements in every benchtop environment. The workflow includes automated online immobilisation, automated sample handling and in-line referencing.

The smart and compact design makes the b-portable very cost effective and keeps maintenance costs minimal.

Software

The bportable software is optimised for touch-screen devices to ensure easy handling and fast setup of the system. It includes a measurement and a data evaluation package.

Measurement, online immobilisation, sample handling and data acquisition are automatised within an user friendly interface. In addition to fast single measurements, you can use pre-programmed protocols for standard applications, such as calibration-free concentration analysis, sandwich assays or binding inhibition. The open data format of the results files also allows the export of data for further evaluation with third party applications and software.

Consumables

b-portable utilises low-cost glass type consumables. The chips are optimised for fast and reliable online immobilisation of biomolecules within the bportable system. Biametrics sensor chips come equipped with various coupling chemistries.