Applications, Knowledge — February 7th, 2019

The potential of label-free screening in drug development

Single colour reflectometry – short SCORE – can be used to analyse the binding characteristics of hundreds to thousands biomolecular interactions without the need for labels. In the past years, label-free kinetic analysis used to be available only for a few lead candidates at the end of a pharmaceutical development process. But with a high throughput technology like SCORE it now is affordable to screen a high number of candidates at the beginning of the development of therapeutic antibodies. … read more

Knowledge — January 23rd, 2018

Seeing is disbelieving – part one

Our guest author Prof. Günter Roth asks the question of how much trust we should put in “established” methods. Can “seeing more” help us to better evaluate our methods and the data generated by them?

… read more

Knowledge — November 27th, 2017

Idle advantages of label-free technologies for new areas of applications

Label-free analysis has made its way in the life sciences and has become a valued tool e.g. in pharmaceutical research. This is mainly due to its outstanding depth of information in combination with its reliable data quality. Yet, many other areas of application might benefit from certain advantages of label-free methods that remained largely unexploited so far. … read more

Knowledge — November 6th, 2017

Size does matter!

At least some say so…

While this is particularly the case in everyday life – not going into details here – it is definitely true in label-free sensing. … read more

Knowledge — September 13th, 2017

Success of Biologics

Biologic therapeutics, like antibody drugs, are predicted to be the future of drug development. How successful are they really? Will biologics soon dominate the pharmaceutical world? … read more

Applications, Knowledge — June 20th, 2017

Poster: simultaneous label-free analysis of 1485 antibody-antigen interactions

A fast and reliable characterisation of protein-protein interactions is essential for various applications in both academic research as well as the chemical and pharmaceutical industry. Label-free technologies do not require a labelling with a reporter substance and enable a real-time monitoring and the determination of kinetic parameters. Many label-free biosensor systems however suffer from a low throughput read-out. … read more

Knowledge — May 1st, 2017

Microbiological diagnostics: will molecular tests replace conventional methods?

A fast but reliable identification of pathogens causing acute infections is a highly important issue in microbiological diagnostics. Conventional culture-based methods are well adapted and quite inexpensive but time-consuming and accompanied by certain limitations. Modern molecular methods have been increasingly incorporated in laboratories, but can they fully replace the traditional microbiological diagnostics? This article will focus on bacterial identification and characterisation methods in microbiological diagnostics including currently used technologies with their advantages and drawbacks. An overview table of the article will summarise all important information. … read more

Knowledge — May 1st, 2017

The dark proteome

Talk about the “dark proteome” has become frequent recently. What lies behind this somewhat mysteriously labelled field of science? And why has it become such a popular topic among scientist and drug developers? … read more