Usage of magnetic nanoparticles for fast extraction and signal enhancement.
As all label-free methods more or less suffer if the size of the analyte is too small, signal enhancement via nanoparticles greatly aids to improve detection limits, especially if the (magnetic) nanoparticles are additionally used for analyte enrichment.
Monitoring of hybridisation and melting processes of DNA-DNA interactions.
In classical DNA experiments, the melting point of a DNA sequence is closely related to the affinity between the two complementary sequences. Due to the temperature stability of the Biametrics technology, it is not only possible to determine the kinetics constants and affinity, but also monitor the melting process.